Apolipoprotein B-to-A1 ratio as a predictor of acute ischemic nonembolic stroke in elderly subjects
Φόρτωση...
Ημερομηνία
Συγγραφείς
Kostapanos, M. S.
Christogiannis, L. G.
Bika, E.
Bairaktari, E. T.
Goudevenos, J. A.
Elisaf, M. S.
Milionis, H. J.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
J Stroke Cerebrovasc Dis
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Among traditional cardiovascular risk factors, apolipoprotein (apo)B/apoA1 ratio is considered to have the strongest predictive value for ischemic stroke. Nevertheless, there are imsufficient data to support this ratio as an independent risk predictor of ischemic stroke in elderly individuals. In this case-control study, we evaluated apoB/apoA1 ratio as a predictor of ischemic stroke in a cohort of elderly subjects. A total of 163 patients aged>70 years (88 men) admitted due to a first-ever acute ischemic/nonembolic stroke and 166 volunteers (87 men) with no history of cardiovascular disease were included. The association between apoB/apoA1 ratio and stroke was determined by multivariate logistic regression modeling after adjusting for potential confounding factors, including lipid parameters. Stroke patients exhibited a higher apoB/apoA1 ratio than controls (1.04+/-0.33 vs 0.86+/-0.22; P<.001). In univariate analysis, crude odds ratio (OR) for apoB/apoA1 ratio was 1.27 per 0.1 increase (95% confidence interval [CI]=1.15-1.39; P<.001). Compared with subjects with an apoB/apoA1 ratio in the lowest quartile, those within the highest quartile had a 6.3-fold increase in the odds of suffering an ischemic stroke (95% CI=3.17-12.48; P<.001). This association remained significant after controlling for potential confounders, including sex, age, smoking status, body mass index, waist circumference, glucose and insulin levels, the presence of hypertension and diabetes mellitus, and lipid profile parameters (adjusted OR=3.02; 95% CI=1.16-7.83; P=.02). Our findings support elevated apoB/apoA1 ratio as an independent predictor of ischemic stroke in individuals over age 70.
Περιγραφή
Λέξεις-κλειδιά
Age Factors, Aged, Aged, 80 and over, Apolipoprotein A-I/*blood, Apolipoproteins B/*blood, Biological Markers/blood, Brain Ischemia/*blood/etiology, Case-Control Studies, Chi-Square Distribution, Cross-Sectional Studies, Female, Greece, Humans, Logistic Models, Male, Odds Ratio, Predictive Value of Tests, Prognosis, Risk Assessment, Risk Factors, Stroke/*blood/etiology, Up-Regulation
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/20538481
http://ac.els-cdn.com/S1052305709001992/1-s2.0-S1052305709001992-main.pdf?_tid=905d9dd2b3fd2f5241b348ce0be1482a&acdnat=1333532660_e52d0c5970307155ddaa25950c998a41
http://ac.els-cdn.com/S1052305709001992/1-s2.0-S1052305709001992-main.pdf?_tid=905d9dd2b3fd2f5241b348ce0be1482a&acdnat=1333532660_e52d0c5970307155ddaa25950c998a41
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής