Identification of photocatalytic degradation products of bezafibrate in TiO2 aqueous suspensions by liquid and gas chromatography

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dc.contributor.authorLambropoulou, D. A.en
dc.contributor.authorHemando, M. D.en
dc.contributor.authorKonstantinou, I. K.en
dc.contributor.authorThurman, E. M.en
dc.contributor.authorFerrer, I.en
dc.contributor.authorAlbanis, T. A.en
dc.contributor.authorFernandez-Alba, A. R.en
dc.date.accessioned2015-11-24T16:39:21Z
dc.date.available2015-11-24T16:39:21Z
dc.identifier.issn0021-9673-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/8147
dc.rightsDefault Licence-
dc.subjectphotocatalysisen
dc.subjecttitanium dioxideen
dc.subjectbezafibrateen
dc.subjectlc-tof-msen
dc.subjectdegradation productsen
dc.subjectpharmaceutical residuesen
dc.subjectpilot-plant scaleen
dc.subjectmass-spectrometryen
dc.subjectoxidation processesen
dc.subjecttitanium-dioxideen
dc.subjectclofibric aciden
dc.subjectwateren
dc.subjectpharmaceuticalsen
dc.subjectozoneen
dc.subjectozonationen
dc.subjectpathwaysen
dc.titleIdentification of photocatalytic degradation products of bezafibrate in TiO2 aqueous suspensions by liquid and gas chromatographyen
heal.abstractIn the present study the photocatalytic degradation of bezafibrate (BZF), a lipid regulator agent, has been investigated using TiO2 suspensions and simulated solar light. The study focus on the identification of degradation products (DPs) using powerful analytical techniques such as liquid chromatography time of flight mass spectrometry (LC-TOF-MS), gas chromatography mass spectrometry (GC-MS), and high-performance liquid chromatography with diode-array detection (HPLC-DAD). Each technique provided complementary information that enabled the identification of 21 DPs. Accurate mass measurements obtained by LC-TOF-MS provided the elucidation of 17 DPs. Mass errors lower than 2 mDa, allowed the assignment of empirical formula for the mayor DPs to be determined confidently. Three DPs were identified by GC-MS through the structural information provided by full scan mass spectra obtained by electron impact (EI) ionization and two more by HPLC-DAD by comparing the retention times (t(R)) and the UV spectra of the unknown DPs with those of commercial standards. Based on this by-product identification a possible multi-step degradation scheme was proposed. The pathways include single or multiple hydroxylation of BZF with subsequent phenoxy ring opening and the cleavage of the amide and ether bonds. (C) 2008 Elsevier B.V. All rights reserved.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDOI 10.1016/j.chroma.2007.12.030-
heal.identifier.secondary<Go to ISI>://000253869900006-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0021967307021772/1-s2.0-S0021967307021772-main.pdf?_tid=e611c0f02897b17e16f8ccfff502f185&acdnat=1333023133_21e7f5e661b6b5be8b2f775dc2cf5c3b-
heal.journalNameJournal of Chromatography Aen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2008-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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