Overexpression of matrix-metalloproteinase-9 in human breast cancer: a potential favourable indicator in node-negative patients

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dc.contributor.authorScorilas, A.en
dc.contributor.authorKarameris, A.en
dc.contributor.authorArnogianaki, N.en
dc.contributor.authorArdavanis, A.en
dc.contributor.authorBassilopoulos, P.en
dc.contributor.authorTrangas, T.en
dc.contributor.authorTalieri, M.en
dc.date.accessioned2015-11-24T16:32:39Z
dc.date.available2015-11-24T16:32:39Z
dc.identifier.issn0007-0920-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/7571
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectBreast Neoplasms/*pathology/surgeryen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectImmunoenzyme Techniquesen
dc.subjectLymph Node Excisionen
dc.subjectMastectomyen
dc.subjectMatrix Metalloproteinase 9/analysis/*biosynthesisen
dc.subjectMiddle Ageden
dc.subjectNeoplasm Invasivenessen
dc.subjectNeoplasm Stagingen
dc.subjectPatieen
dc.titleOverexpression of matrix-metalloproteinase-9 in human breast cancer: a potential favourable indicator in node-negative patientsen
heal.abstractMatrix metalloprotease-9 (MMP-9; 92 kDa type IV collaganase, gelatinase B) is regarded as, important for degradation of the basement membrane and extracellular matrix during cancer invasion and other tissue-remodelling events. In this study we evaluate the prognostic value of MMP-9, by immunoperoxidase staining in a series of 210 breast cancer tissues. The results were quantitated using the HSCORE system, which consider both staining intensity and the percentage of cells stained at given intensities. MMP-9 status was compared with the concentration of cytosolic Cathepsin-D and with other established prognostic factors, in terms of disease free survival and overall survival. The median follow-up period was 62 months. MMP-9 staining was observed primarily in cancer cells, and to a lesser degree in surrounding stromal cells. MMP-9 expression was not detected in normal breast tissue. Levels of MMP-9 expression below the cut-off point were more frequently observed in larger (P = 0.014), invasive ductal histologic (P = 0.037), progesterone receptor (PR)-negative and PR-strong positive tumours (P< 0.001), as well as samples belonging to patients with stage III-IV disease (P = 0.009) and age 45-55 years (P = 0.011). In univariate analysis, node-negative breast cancer patients with tumors positive for MMP-9 had a considerable reduction in risk for relapse (RR = 0.45;P = 0.039) or death (RR = 0.32;P = 0.009). Multivariate analysis indicated that MMP-9 status was an independent favourable predictor of OS (RR = 0.47;P = 0.034) in node-negative but not in node-positive patients. Our results suggest that MMP-9 may be an independent favourable prognostic factor in node-negative breast cancer patients. The overexpression of MMP-9 in breast cancer may be also used as a marker to subdivide node negative breast cancer patients in order to determine the optimal treatment modality.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1054/bjoc.2001.1810-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/11384099-
heal.identifier.secondaryhttp://www.nature.com/bjc/journal/v84/n11/pdf/6691810a.pdf-
heal.journalNameBr J Canceren
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2001-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιώνel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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