Metsovo-tremolite asbestos fibres: in vitro effects on mutation, chromosome aberration, cell transformation and intercellular communication
Φόρτωση...
Ημερομηνία
Συγγραφείς
Athanasiou, K.
Constantopoulos, S. H.
Rivedal, E.
Fitzgerald, D. J.
Yamasaki, H.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Mutagenesis
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Samples of Metsovo-tremolite asbestos, previously found to be the causative agent of endemic pleural calcification and an increased level of malignant pleural mesothelioma in a rural area of north-western Greece (Metsovo area), were tested in various in vitro toxicity test systems. It was found that asbestos fibres of this type were strong inducers of micronuclei and numerical chromosomal abnormalities while they induced low levels of chromosomal aberrations in mammalian cells in culture. Furthermore, this type of asbestos can induce a low level of in vitro transformation of Syrian hamster embryo cells. The fibres had no effect on gap-junctional cell-cell communication (followed by the dye-transfer method) and did not induce any mutations in the Salmonella typhimurium strain TA102 which is known to be sensitive to the action of various oxidative agents. These results support the hypothesis generated from studies on other types of asbestos that such fibres induce tumours by causing chromosomal mutations.
Περιγραφή
Λέξεις-κλειδιά
Aneuploidy, Animals, Asbestos/adverse effects/pharmacology/*toxicity, *Asbestos, Amphibole, Cell Communication/*drug effects, Cell Line, Cell Transformation, Neoplastic/*chemically induced, *Chromosome Aberrations, Cricetinae, Cricetulus, Greece, Humans, Incidence, Mesocricetus, Mesothelioma/epidemiology/etiology, Micronucleus Tests, *Mutagenesis, Mutagenicity Tests, Pleural Neoplasms/epidemiology/etiology, Salmonella typhimurium/drug effects, Silicic Acid/adverse effects/pharmacology/*toxicity
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/1470029
http://mutage.oxfordjournals.org/content/7/5/343
http://mutage.oxfordjournals.org/content/7/5/343
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής