Macrophage activation and antitumor activity of a Brucella abortus ether extract, Bru-Pel
| dc.contributor.author | Schultz, R. M. | en |
| dc.contributor.author | Chirigos, M. A. | en |
| dc.contributor.author | Pavlidis, N. A. | en |
| dc.contributor.author | Youngner, J. S. | en |
| dc.date.accessioned | 2015-11-24T19:05:52Z | |
| dc.date.available | 2015-11-24T19:05:52Z | |
| dc.identifier.issn | 0361-5960 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/20257 | |
| dc.rights | Default Licence | - |
| dc.subject | Animals | en |
| dc.subject | Brucella Vaccine/isolation & purification/*pharmacology | en |
| dc.subject | Brucella abortus/immunology | en |
| dc.subject | Cytotoxicity, Immunologic | en |
| dc.subject | Lipopolysaccharides/immunology | en |
| dc.subject | Lung Neoplasms/immunology/*prevention & control | en |
| dc.subject | Macrophages/*immunology | en |
| dc.subject | Male | en |
| dc.subject | Mice | en |
| dc.subject | Mice, Inbred Strains | en |
| dc.subject | Neoplasm Metastasis/*prevention & control | en |
| dc.subject | Neoplasms, Experimental/prevention & control | en |
| dc.title | Macrophage activation and antitumor activity of a Brucella abortus ether extract, Bru-Pel | en |
| heal.abstract | Bru-Pel and Brucella abortus lipopolysaccharide (LPS) were tested for both macrophage activation and antitumor activity in an artificial metastasis model. Resting macrophages were rendered nonspecifically tumoricidal for MBL-2 lymphoblastic leukemia target cells by exposure to Bru-Pel at greater than or equal to 1 ng/ml of culture medium. B. abortus LPS failed to activate macrophages in vitro at all concentrations tested. Ip treatment of homozygous nude mice with Bru-Pel induced cytotoxic macrophages, indicating that Bru-Pel activated macrophages through a thymic-independent process. An artificial metastasis model was developed where single-cell suspensions of Madison 109 lung carcinoma were inoculated iv into syngeneic BALB/c mice. Bru-Pel, but not B. abortus LPS, strikingly inhibited tumor-colony formation in the lungs. Although Bru-Pel contains endotoxin, the data demonstrate that endotoxin is apparently not the active component by which Bru-Pel activates macrophages and enhances host resistance to cancer. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/103619 | - |
| heal.journalName | Cancer Treat Rep | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1978 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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