Alterations in cell death and cell cycle progression in the UV-irradiated epidermis of bcl-2-deficient mice
| dc.contributor.author | Gillardon, F. | en |
| dc.contributor.author | Moll, I. | en |
| dc.contributor.author | Meyer, M. | en |
| dc.contributor.author | Michaelidis, T. M. | en |
| dc.date.accessioned | 2015-11-24T16:32:08Z | |
| dc.date.available | 2015-11-24T16:32:08Z | |
| dc.identifier.issn | 1350-9047 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/7519 | |
| dc.rights | Default Licence | - |
| dc.subject | ultraviolet radiation | en |
| dc.subject | bcl-2 gene targeting | en |
| dc.subject | DNA damage | en |
| dc.subject | apoptosis | en |
| dc.subject | proliferation | en |
| dc.subject | melanocytes | en |
| dc.subject | keratinocytes | en |
| dc.subject | in-vivo | en |
| dc.subject | c-fos | en |
| dc.subject | ultraviolet-radiation | en |
| dc.subject | induced apoptosis | en |
| dc.subject | gene-expression | en |
| dc.subject | skin-cancer | en |
| dc.subject | DNA-damage | en |
| dc.subject | bcl-2 | en |
| dc.subject | activation | en |
| dc.subject | differentiation | en |
| dc.title | Alterations in cell death and cell cycle progression in the UV-irradiated epidermis of bcl-2-deficient mice | en |
| heal.abstract | The effect of bcl-2 gene ablation on epidermal cell death induced by UV-B irradiation was investigated in mice. Exposure of depilated back skin of bcl-2(-/-) mice to 0.5 J/ cm(2) UV-B caused a prolonged increase in the number of epidermal cells showing nuclear DNA fragmentation compared to wild-type littermates. Consistently, skin explants from bcl-2-deficient mice exhibited a higher number of sunburn cells per cm epidermis (16.6 +/- 2.1 vs 7.0 +/- 1.5) following exposure to 0.1 J/cm(2) UV-B in vitro, Furthermore, UV irradiation failed to increase pre-melanosomes in skin explants from mutant animals, and primary menalocyte cultures derived from bcl-2 null mutants were highly susceptible to UV-induced cell death compared to cultures from wild-type littermates, An accelerated reappearance of proliferating cells, showing nuclear immunoreactivity for Ki-67 and c-Fos, was observed in the UV-irradiated epidermis of bcl-2-deficient mice. Taken together, these findings suggest that effects of UV radiation on epidermal cell death and cell cycle progression are influenced by survival-promoting Bcl-2. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | <Go to ISI>://000078212000009 | - |
| heal.journalName | Cell Death Differ | en |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1999 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιών | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
Αρχεία
Φάκελος/Πακέτο αδειών
1 - 1 of 1
Φόρτωση...
- Ονομα:
- license.txt
- Μέγεθος:
- 1.74 KB
- Μορφότυπο:
- Item-specific license agreed upon to submission
- Περιγραφή: