Esophageal squamous cell carcinomas and expression of p53, Bcl-2, and Bcl-X(L)

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dc.contributor.authorVlachos, K.en
dc.contributor.authorSiafakas, N.en
dc.contributor.authorKarameris, A.en
dc.contributor.authorTheodoropoulos, G.en
dc.contributor.authorParassi, E.en
dc.contributor.authorPeros, G.en
dc.contributor.authorPapadopoulos, J.en
dc.contributor.authorHakim, N.en
dc.date.accessioned2015-11-24T19:18:22Z
dc.date.available2015-11-24T19:18:22Z
dc.identifier.issn0020-8868-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21861
dc.rightsDefault Licence-
dc.subjectApoptosisen
dc.subjectCarcinoma, Squamous Cell/*chemistry/pathologyen
dc.subjectCell Differentiationen
dc.subjectEsophageal Neoplasms/*chemistry/pathologyen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subjectLymphatic Metastasisen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectProto-Oncogene Proteins c-bcl-2/*analysisen
dc.subjectTumor Suppressor Protein p53/*analysisen
dc.subjectbcl-X Protein/*analysisen
dc.titleEsophageal squamous cell carcinomas and expression of p53, Bcl-2, and Bcl-X(L)en
heal.abstractp53 protein promotes apoptosis, whereas Bcl-2 family proteins have an antiapoptotic function. This study determines the predictive value of selected clinical and histopathological factors in correlation with the expression of p53, Bcl-2, and Bcl-X(L) proteins in esophageal squamous cell carcinomas (SCCs). Paraffin-embedded sections from 19 surgically resected primary esophageal SCCs were examined by immunohistochemistry. p53 expression was related to degree of tumor differentiation (P = 0.044). Bcl-2 expression was associated with regional lymph node metastasis (P = 0.053), whereas Bcl-X(L) expression was correlated with distant metastasis (P = 0.060) and with the expression of Bcl-2 protein (P = 0.068). p53 and Bcl-2 family proteins may help to estimate the properties of esophageal SCCs and provide useful information to the oncologist for the selection of patients for intensive combined therapy modalities with curative intention or for palliative therapy.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/18998283-
heal.journalNameInt Surgen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2008-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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