Vinorelbine in combination with interleukin-2 as second-line treatment in patients with metastatic melanoma. A phase II study of the Hellenic Cooperative Oncology Group

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dc.contributor.authorGogas, H.en
dc.contributor.authorBafaloukos, D.en
dc.contributor.authorAravantinos, G.en
dc.contributor.authorFountzilas, G.en
dc.contributor.authorTsoutsos, D.en
dc.contributor.authorPanagiotou, P.en
dc.contributor.authorFrangia, K.en
dc.contributor.authorKalofonos, H. P.en
dc.contributor.authorBriasoulis, E.en
dc.contributor.authorCastana, O.en
dc.contributor.authorPolyzos, A.en
dc.contributor.authorPectasides, D.en
dc.contributor.authorIoannovich, J.en
dc.date.accessioned2015-11-24T19:43:23Z
dc.date.available2015-11-24T19:43:23Z
dc.identifier.issn0735-7907-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24749
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAntineoplastic Combined Chemotherapy Protocols/adverse effects/*therapeutic useen
dc.subjectDisease Progressionen
dc.subjectDrug Resistance, Neoplasmen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectInterleukin-2/administration & dosageen
dc.subjectMaleen
dc.subjectMelanoma/*drug therapy/pathology/secondaryen
dc.subjectMiddle Ageden
dc.subjectSalvage Therapyen
dc.subjectSkin Neoplasms/*drug therapy/pathologyen
dc.subjectSurvival Rateen
dc.subjectTime Factorsen
dc.subjectVinblastine/administration & dosage/*analogs & derivativesen
dc.titleVinorelbine in combination with interleukin-2 as second-line treatment in patients with metastatic melanoma. A phase II study of the Hellenic Cooperative Oncology Groupen
heal.abstractOBJECTIVES: To evaluate the efficacy and toxicity of the combination of vinorelbine and interleukin (IL)-2 in patients with metastatic melanoma as second-line chemotherapy. PATIENTS AND METHODS: Twenty-two patients with histologically confirmed stage IV melanoma previously treated with temozolomide-based chemotherapy--only one regimen of chemotherapy for disseminated disease was allowed--were treated with vinorelbine 30 mg/m2 on days 1 and 15 and IL-2 subcutaneous 9 x 10(6) once daily on days 2-6 and 16-19 every 4 weeks for maximum of six cycles. RESULTS: From January 2000 to July 2001, 22 patients entered the study; the median age was 56 years. Among 20 evaluable patients there were 2 (9.1%) objective responses including 1 complete response and 1 partial response. Five (22.7%) had stabilization of their disease, and 13 (59.1%) progressed. The median time to progression (TTP) was 2.9 months and the median overall survival was 9.1 months. There was a significant difference in TTP in patients who responded or remained stable (median TTP 10.75 months) and those who progressed (median TTP 2.1 months) (p<0.05). There was also a difference in survival in the two groups (p<0.05 (28 vs. 8 months). The most common side effects were flulike symptoms, such as fever, chills, fatigue, and injection site reaction. Grade 3 hematological toxicity rarely occurred. One patient discontinued therapy because of fatigue and anorexia. There were no treatment-related deaths. CONCLUSIONS: The combination of vinorelbine and IL-2 provides clinical benefit in patients recurring or progressing on first-line chemotherapy for metastatic melanoma, with manageable toxicity.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/15641480-
heal.identifier.secondaryhttp://informahealthcare.com/doi/abs/10.1081/CNV-200039630-
heal.journalNameCancer Investen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2004-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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