The expression of myc and ras oncogene protein in childhood lymphomas
| dc.contributor.author | Sakalidou, A. | en |
| dc.contributor.author | Kanavaros, P. | en |
| dc.contributor.author | Tzardi, M. | en |
| dc.contributor.author | Kalmanti, M. | en |
| dc.date.accessioned | 2015-11-24T19:41:30Z | |
| dc.date.available | 2015-11-24T19:41:30Z | |
| dc.identifier.issn | 0250-7005 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/24489 | |
| dc.rights | Default Licence | - |
| dc.subject | Adolescent | en |
| dc.subject | Child | en |
| dc.subject | Child, Preschool | en |
| dc.subject | Hodgkin Disease/*metabolism/pathology | en |
| dc.subject | Humans | en |
| dc.subject | Immunohistochemistry | en |
| dc.subject | Lymphoma, Non-Hodgkin/*chemistry/pathology | en |
| dc.subject | Lymphoma, T-Cell/chemistry/pathology | en |
| dc.subject | Paraffin Embedding | en |
| dc.subject | Proto-Oncogene Proteins c-myc/*analysis | en |
| dc.subject | ras Proteins/*analysis | en |
| dc.title | The expression of myc and ras oncogene protein in childhood lymphomas | en |
| heal.abstract | Paraffin sections from 21 cases of Hodgkin's disease (HD), 18 cases of non-Hodgkin's lymphomas (NHL) and 15 cases of reactive lymphadenitides occurring in children 3-15 years old were examined by immunohistochemistry for the presence of c-myc and pan-ras oncogene products. In all cases of childhood lymphomas studied c-myc protein was expressed. The highest percentage was in HD where in 29% of cases the percentage of positive cells was greater than 20%, while in only 6% of NHL cases this percentage was noted. In all cases of reactive lymphadenitides the number of cells where c-myc was expressed was less than 5%. The ras oncogene was also found in HD but with a lesser degree of positivity than c-myc. In 48% of these cases the number of positive cells ranged between 2 and 10%, while in NHL and in reactive lymphadenitides there was no positivity. The above results indicate a frequent expression of c-myc protein in childhood lymphomas. This could reflect either an implication of c-myc oncogene in the pathogenesis of these tumor or an epiphenomenon of lymphomagenesis reflecting the proliferation rate of tumor cell population. Molecular biology studies are needed to clarify this issue. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/8615659 | - |
| heal.journalName | Anticancer Res | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1996 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
Αρχεία
Φάκελος/Πακέτο αδειών
1 - 1 of 1
Φόρτωση...
- Ονομα:
- license.txt
- Μέγεθος:
- 1.74 KB
- Μορφότυπο:
- Item-specific license agreed upon to submission
- Περιγραφή: