Fraction of the peripheral blood concentration of CD56+/CD16-/CD3- cells in total natural killer cells as an indication of fertility and infertility

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dc.contributor.authorMichou, V. I.en
dc.contributor.authorKanavaros, P.en
dc.contributor.authorAthanassiou, V.en
dc.contributor.authorChronis, G. B.en
dc.contributor.authorStabamas, S.en
dc.contributor.authorTsilivakos, V.en
dc.date.accessioned2015-11-24T19:15:25Z
dc.date.available2015-11-24T19:15:25Z
dc.identifier.issn0015-0282-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21509
dc.rightsDefault Licence-
dc.subjectAbortion, Habitual/blood/immunologyen
dc.subjectAdulten
dc.subjectAntigens, CD/*blooden
dc.subjectAntigens, CD3/blooden
dc.subjectAntigens, CD56/blooden
dc.subjectCase-Control Studiesen
dc.subjectEndometrium/immunologyen
dc.subjectFemaleen
dc.subjectFertility/*immunologyen
dc.subjectFlow Cytometryen
dc.subjectHumansen
dc.subjectImmunophenotypingen
dc.subjectInfertility, Female/blood/*immunologyen
dc.subjectKiller Cells, Natural/*immunologyen
dc.subjectLinear Modelsen
dc.subjectLymphocyte Subsets/immunologyen
dc.subjectMultivariate Analysisen
dc.subjectPregnancyen
dc.subjectReceptors, IgG/blooden
dc.titleFraction of the peripheral blood concentration of CD56+/CD16-/CD3- cells in total natural killer cells as an indication of fertility and infertilityen
heal.abstractOBJECTIVE: To determine whether the peripheral blood concentration of CD56(+)/CD16(-)/CD3(-) cells, the main natural killer (NK) subpopulation that colonizes the endometrium in the middle and late secretory phase, can be related to fertility or infertility status. DESIGN: A case control study. SETTING: Immunopathology department of an infertility laboratory. PATIENTS: A total 99 women were selected (group I: consecutive spontaneous aborters, n = 25; group II: sporadic spontaneous aborters, n = 30; group III: infertile, n = 33; group IV: controls, n = 11). INTERVENTION: Immunophenotyping of women grouped according to their fertility status. MAIN OUTCOME MEASURES: Peripheral blood lymphocytes were examined by two- and three-color flow cytometry. RESULTS: A statistically significant association between endometrial-type peripheral blood (PB) NK cell concentrations and fertility status (groups I and IV vs. groups II and III) was documented. The %(/TOTAL PB)(CD56+CD16-CD3-) NK cells was significantly higher [1] in fertile (groups I and IV) than in sporadic aborters/infertile (groups II and III) women, [2] in group I when compared with groups II and III, and [3] in group IV when compared with groups II and III. CONCLUSIONS: This study indicates that diminished numbers of the %(/TOTAL PB)(CD56+CD16-CD3-) NK cells are related to sporadic aborters and infertile women. Thus, the fraction could be used as an indicator of subsequent successful implantation and maintenance of gestation.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/14505740-
heal.journalNameFertil Sterilen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2003-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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