H-1 NMR study of the enantioselective binding of Lambda- and Delta-[Ru(bpy)(2)(m-bpy-GHK)]Cl-2 to the deoxynucleotide duplex d(5 '-C(1)G(2)C(3)G(4)A(5)A(6)T(7)T(8)C(9)G(10)C(11)G(12)-3 ')(2)
| dc.contributor.author | Myari, A. | en |
| dc.contributor.author | Hadjiliadis, N. | en |
| dc.contributor.author | Garoufis, A. | en |
| dc.date.accessioned | 2015-11-24T16:38:35Z | |
| dc.date.available | 2015-11-24T16:38:35Z | |
| dc.identifier.issn | 1565-3633 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/8062 | |
| dc.rights | Default Licence | - |
| dc.subject | DNA-binding | en |
| dc.subject | peptide complexes | en |
| dc.subject | crystal-structure | en |
| dc.subject | nucleic-acids | en |
| dc.subject | minor-groove | en |
| dc.subject | sequence | en |
| dc.subject | intercalation | en |
| dc.subject | endonuclease | en |
| dc.subject | recognition | en |
| dc.subject | drug | en |
| dc.title | H-1 NMR study of the enantioselective binding of Lambda- and Delta-[Ru(bpy)(2)(m-bpy-GHK)]Cl-2 to the deoxynucleotide duplex d(5 '-C(1)G(2)C(3)G(4)A(5)A(6)T(7)T(8)C(9)G(10)C(11)G(12)-3 ')(2) | en |
| heal.abstract | The interaction of the diastereomeric complexes Lambda- and Delta-[Ru(bpy)(2)(m-GHK)]Cl-2, (GHK = glycine-histidine-lysine) to the deoxynucleotide duplex d(5 '-CGCGAATTCGCG-3 ')(2) was studied by means of H-1 NMR spectroscopy. The diastereomers interact with the oligonucleotide duplex differently. The Delta-[Ru(bpy)(2)(m-GHK)]Cl-2 is characterized by major groove binding close to the central part of the oligonucleotide, with both the peptide and the bipyridine ligand of the complex involved in the binding. The Delta-[Ru(bpy)(2)(m-bpy-GHK)]Cl-2 binds loosely, approaching the helix from the minor groove. The NMR analysis shows that the peptide (GHK) binding has a determinative role in the interactions of both diastereomers with the oligonucleotide. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | <Go to ISI>://000229308800009 | - |
| heal.identifier.secondary | http://downloads.hindawi.com/journals/bca/2005/765234.pdf | - |
| heal.journalName | Bioinorg Chem Appl | en |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2005 | - |
| heal.publisher | Hindawi Publishing Corporation | en |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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