SoxC Transcription Factors Are Required for Neuronal Differentiation in Adult Hippocampal Neurogenesis

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dc.contributor.authorMu, L. F.en
dc.contributor.authorBerti, L.en
dc.contributor.authorMasserdotti, G.en
dc.contributor.authorCovic, M.en
dc.contributor.authorMichaelidis, T. M.en
dc.contributor.authorDoberauer, K.en
dc.contributor.authorMerz, K.en
dc.contributor.authorRehfeld, F.en
dc.contributor.authorHaslinger, A.en
dc.contributor.authorWegner, M.en
dc.contributor.authorSock, E.en
dc.contributor.authorLefebvre, V.en
dc.contributor.authorCouillard-Despres, S.en
dc.contributor.authorAigner, L.en
dc.contributor.authorBerninger, B.en
dc.contributor.authorLie, D. C.en
dc.date.accessioned2015-11-24T16:34:49Z
dc.date.available2015-11-24T16:34:49Z
dc.identifier.issn0270-6474-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/7858
dc.rightsDefault Licence-
dc.subjectneural stem-cellsen
dc.subjectnewly generated neuronsen
dc.subjectcentral-nervous-systemen
dc.subjectstage-specific roleen
dc.subjectin-vivoen
dc.subjectpostnatal astrogliaen
dc.subjectanalysis revealsen
dc.subjectDNA-bindingen
dc.subjectexpressionen
dc.subjectgeneen
dc.titleSoxC Transcription Factors Are Required for Neuronal Differentiation in Adult Hippocampal Neurogenesisen
heal.abstractNeural stem cells (NSCs) generate new hippocampal dentate granule neurons throughout adulthood. The genetic programs controlling neuronal differentiation of adult NSCs are only poorly understood. Here we show that, in the adult mouse hippocampus, expression of the SoxC transcription factors Sox4 and Sox11 is initiated around the time of neuronal commitment of adult NSCs and is maintained in immature neurons. Overexpression of Sox4 and Sox11 strongly promotes in vitro neurogenesis from adult NSCs, whereas ablation of Sox4/Sox11 prevents in vitro and in vivo neurogenesis from adult NSCs. Moreover, we demonstrate that SoxC transcription factors target the promoters of genes that are induced on neuronal differentiation of adult NSCs. Finally, we show that reprogramming of astroglia into neurons is dependent on the presence of SoxC factors. These data identify SoxC proteins as essential contributors to the genetic network controlling neuronal differentiation in adult neurogenesis and neuronal reprogramming of somatic cells.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDoi 10.1523/Jneurosci.4679-11.2012-
heal.identifier.secondary<Go to ISI>://000300938100014-
heal.identifier.secondaryhttp://www.jneurosci.org/content/32/9/3067-
heal.journalNameJournal of Neuroscienceen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2012-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιώνel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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