Elevated interleukin-1 beta in the circulation of patients with essential hypertension before any drug therapy: a pilot study
| dc.contributor.author | Dalekos, G. N. | en |
| dc.contributor.author | Elisaf, M. S. | en |
| dc.contributor.author | Papagalanis, N. | en |
| dc.contributor.author | Tzallas, C. | en |
| dc.contributor.author | Siamopoulos, K. C. | en |
| dc.date.accessioned | 2015-11-24T19:20:00Z | |
| dc.date.available | 2015-11-24T19:20:00Z | |
| dc.identifier.issn | 0014-2972 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/22003 | |
| dc.rights | Default Licence | - |
| dc.subject | Adult | en |
| dc.subject | Aged | en |
| dc.subject | Female | en |
| dc.subject | Humans | en |
| dc.subject | Hypertension/drug therapy/*immunology | en |
| dc.subject | Interleukin-1/*blood | en |
| dc.subject | Male | en |
| dc.subject | Middle Aged | en |
| dc.subject | Pilot Projects | en |
| dc.subject | Receptors, Interleukin-2/analysis | en |
| dc.title | Elevated interleukin-1 beta in the circulation of patients with essential hypertension before any drug therapy: a pilot study | en |
| heal.abstract | Immune system disturbances have been implicated in the pathogenesis of essential hypertension. The aim of this study was to determine the levels of the interleukin-1 beta and soluble interleukin-2 receptors in serum samples from 114 hypertensive patients before any drug therapy because there are no well-established data regarding these immunologic mediators in essential hypertension. We found increased levels of interleukin-1 beta in 59.6% of patients, while soluble interleukin-2 receptors were not detected. The interleukin-1 beta levels were significantly higher in patients than in healthy controls (P = 0.0001). We conclude that patients with essential hypertension have high levels of interleukin-1 beta but not indicators of cellular immune activation in their sera. Further studies are in progress in order to confirm, explain and assess the clinical utility of the above findings. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/8911869 | - |
| heal.identifier.secondary | http://onlinelibrary.wiley.com/store/10.1111/j.1365-2362.1996.tb02141.x/asset/j.1365-2362.1996.tb02141.x.pdf?v=1&t=h0m4gqjp&s=a901534ba932ddfd25a2c12135889b827759693c | - |
| heal.journalName | Eur J Clin Invest | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1996 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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