Autoantibodies to HMG-17 nucleosomal protein in patients with scleroderma
Φόρτωση...
Ημερομηνία
Συγγραφείς
Vlachoyiannopoulos, P. G.
Boumba, V. A.
Tzioufas, A. G.
Seferiadis, C.
Tsolas, O.
Moutsopoulos, H. M.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
J Autoimmun
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Autoantibodies to HMG-17, a non-histone nucleosomal protein, were found in systemic lupus erythematosus (SLE), mixed connective tissue disease (MCTD) and ANA positive pauciarticular juvenile rheumatoid arthritis (JRA), but not in rheumatoid arthritis (RA). Using highly purified HMG-17 derived from porcine thymus, we tested sera from 50 patients with scleroderma for antibodies to HMG-17 by enzyme-linked immunosorbent assay (ELISA). There were 16 patients with diffuse cutaneous systemic sclerosis (dSSc) and 34 with limited cutaneous systemic sclerosis (1SSc) with age at disease onset 40.25 +/- 11.68 and 39.94 +/- 15.68 years, respectively, and disease duration 6.03 +/- 4.98 and 13.34 +/- 11.80 years, respectively (P < 0.0001). Anticentromere antibodies (ACA) were found in 65% of 1SSc patients but not in dSSc (P < 0.0001) while the prevalence of antinuclear antibodies (ANA) with other than ACA patterns did not differ in the two groups. Anti-HMG-17 antibodies occurred in 20 patients (40%), five with dSSc (31%) and 15 with 1SSc (41%). Twelve of the 20 HMG-17 positive patients were also positive for ACA (60%) but this association was not significant. No association was found between anti-HMG-17 and other antibody patterns. In conclusion, anti-HMG-17 antibodies occur in one third of scleroderma patients, do not discriminate scleroderma variants and are not associated with other autoantibodies.
Περιγραφή
Λέξεις-κλειδιά
Adult, Antibodies, Antinuclear/*blood, Autoimmune Diseases/immunology, Electrophoresis, Polyacrylamide Gel, Enzyme-Linked Immunosorbent Assay, Female, High Mobility Group Proteins/*immunology, Humans, Male, Middle Aged, Nucleosomes/immunology, Scleroderma, Localized/*immunology, Scleroderma, Systemic/*immunology
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/8037838
http://ac.els-cdn.com/S0896841184710158/1-s2.0-S0896841184710158-main.pdf?_tid=d2472e5b0e3ded512188f914facaca40&acdnat=1337849259_809f9c371777a0b010d42cf44272115a
http://ac.els-cdn.com/S0896841184710158/1-s2.0-S0896841184710158-main.pdf?_tid=d2472e5b0e3ded512188f914facaca40&acdnat=1337849259_809f9c371777a0b010d42cf44272115a
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής