Effects of CCR5-delta32 and CCR2-64I alleles on disease progression of perinatally HIV-1-infected children: an international meta-analysis

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dc.contributor.authorIoannidis, J. P.en
dc.contributor.authorContopoulos-Ioannidis, D. G.en
dc.contributor.authorRosenberg, P. S.en
dc.contributor.authorGoedert, J. J.en
dc.contributor.authorDe Rossi, A.en
dc.contributor.authorEspanol, T.en
dc.contributor.authorFrenkel, L.en
dc.contributor.authorMayaux, M. J.en
dc.contributor.authorNewell, M. L.en
dc.contributor.authorPahwa, S. G.en
dc.contributor.authorRousseau, C.en
dc.contributor.authorScarlatti, G.en
dc.contributor.authorSei, S.en
dc.contributor.authorSen, L.en
dc.contributor.authorO'Brien, T. R.en
dc.date.accessioned2015-11-24T19:21:41Z
dc.date.available2015-11-24T19:21:41Z
dc.identifier.issn0269-9370-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22116
dc.rightsDefault Licence-
dc.subject*Allelesen
dc.subjectChilden
dc.subjectChild, Preschoolen
dc.subjectDatabases, Factualen
dc.subjectDisease Progressionen
dc.subjectFollow-Up Studiesen
dc.subjectGenotypeen
dc.subjectHIV Infections/*genetics/mortalityen
dc.subject*Hiv-1en
dc.subjectHumansen
dc.subjectInfanten
dc.subjectInfant, Newbornen
dc.subjectOdds Ratioen
dc.subjectProportional Hazards Modelsen
dc.subjectProspective Studiesen
dc.subjectReceptors, CCR2en
dc.subjectReceptors, CCR5/*geneticsen
dc.subjectReceptors, Chemokine/*geneticsen
dc.subjectSurvival Analysisen
dc.subjectTime Factorsen
dc.titleEffects of CCR5-delta32 and CCR2-64I alleles on disease progression of perinatally HIV-1-infected children: an international meta-analysisen
heal.abstractOBJECTIVE: Among perinatally infected children, the effects of certain alleles of the CCR5 and CCR2 genes on the rate of disease progression remain unclear. We addressed the effects of CCR5-delta32 and CCR2-64I in an international meta-analysis. METHODS: Genotype data were contributed from 10 studies with 1317 HIV-1-infected children (7263 person-years of follow-up). Time-to-event analyses were performed stratified by study and racial group. Endpoints included progression to clinical AIDS, death, and death after the diagnosis of clinical AIDS. The time-dependence of the genetic effects was specifically investigated. RESULTS: There was large heterogeneity in the observed rates of disease progression between different cohorts. For progression to clinical AIDS, both CCR5-delta32 and CCR2-64I showed overall non-significant trends for protection [hazard ratios 0.84, 95% confidence interval (CI) 0.58-1.23; and 0.87, 95% CI 0.67-1.14, respectively]. However, analyses of survival showed statistically significant time-dependence. No deaths occurred among CCR5-delta32 carriers in the first 3 years of life, whereas there was no protective effect (hazard ratio 0.95; 95% CI 0.43-2.10) in later years (P=0.01 for the time-dependent model). For CCR2-64I, the hazard ratio for death was 0.69 (95% CI 0.39-1.21) in the first 6 years of life and 2.56 (95% CI 1.26-5.20) in subsequent years (P<0.01 for the time-dependent model). CCR5-delta32 and CCR2-64I offered no clear protection after clinical AIDS had developed. CONCLUSION: The CCR5-delta32 and CCR2-64I alleles are associated with a decreased risk of death among perinatally infected children, but only for the first years of life.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1097/01.aids.0000060411.18106.0f-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/12853745-
heal.journalNameAIDSen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2003-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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