Expression of c-myc and bcl-2 oncogene products in Reed-Sternberg cells independent of presence of Epstein-Barr virus

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dc.contributor.authorJiwa, N. M.en
dc.contributor.authorKanavaros, P.en
dc.contributor.authorvan der Valk, P.en
dc.contributor.authorWalboomers, J. M.en
dc.contributor.authorHorstman, A.en
dc.contributor.authorVos, W.en
dc.contributor.authorMullink, H.en
dc.contributor.authorMeijer, C. J.en
dc.date.accessioned2015-11-24T19:16:43Z
dc.date.available2015-11-24T19:16:43Z
dc.identifier.issn0021-9746-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21703
dc.rightsDefault Licence-
dc.subjectAntigens, Viral/analysisen
dc.subjectBase Sequenceen
dc.subjectDNA, Viral/analysisen
dc.subjectGene Expression Regulation, Neoplasticen
dc.subjectHerpesvirus 4, Human/*genetics/isolation & purificationen
dc.subjectHodgkin Disease/*metabolism/microbiologyen
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subjectIn Situ Hybridizationen
dc.subjectMolecular Sequence Dataen
dc.subjectPolymerase Chain Reactionen
dc.subjectProto-Oncogene Proteins/*analysis/geneticsen
dc.subjectProto-Oncogene Proteins c-myc/*analysis/geneticsen
dc.subjectReed-Sternberg Cells/*chemistry/microbiologyen
dc.subjectViral Envelope Proteins/analysisen
dc.subjectViral Matrix Proteins/analysisen
dc.titleExpression of c-myc and bcl-2 oncogene products in Reed-Sternberg cells independent of presence of Epstein-Barr virusen
heal.abstractAIMS: To evaluate the expression of c-myc and bcl-2 oncogene products in Reed-Sternberg cells in Hodgkin's disease, especially in relation to Epstein-Barr virus infection and expression of EBV encoded latent membrane protein (LMP). METHODS: Tissues from 33 cases of Hodgkin's disease were studied for the presence of EBV DNA by polymerase chain reaction (PCR) and DNA in situ hybridisation (DISH), for the presence of EBER-1 and EBER-2 EBV RNA by RNA in situ hybridisation (RISH); and for the presence of LMP, bcl-2, and c-myc proteins by immunohistochemical staining. RESULTS: A substantial number of Reed-Sternberg cells expressed bcl-2 in 20 of 29 (69%) and c-myc in 30 of 32 (94%) Hodgkin's disease samples. In 18 of the 25 (72%) cases Reed-Sternberg cells expressed both oncogene products. Of these 18 cases, 10 (56%) were EBV-PCR positive; eight (44%) were EBV-PCR negative. CONCLUSIONS: Reed-Sternberg cells in Hodgkin's disease frequently express both bcl-2 and c-myc oncogene products, suggesting that these oncogenes may act in concert in the pathogenesis of the disease. Moreover, the expression of c-myc and bcl-2 proteins in Reed-Sternberg cells is independent of EBV and LMP status.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/8385158-
heal.identifier.secondaryhttp://jcp.bmj.com/content/46/3/211.full.pdf-
heal.journalNameJ Clin Patholen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1993-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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