Lipid peroxidation and the use of emulsified propofol in laparoscopic surgery
Φόρτωση...
Ημερομηνία
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Surgical Endoscopy-Ultrasound and Interventional Techniques
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Background: Free radical-induced lipid peroxidation associated with a decrease of antioxidant capacity in plasma is observed after the deflation of the pneumoperitoneum in laparoscopic surgery. In this study, we evaluated the effect of the continuous administration of lipid peroxidation derivatives on emulsified propofol. Methods: Two groups of 20 patients each who underwent laparoscopic surgery were studied prospectively. Maintenance of anesthesia was achieved with 66% nitrous oxide and either isoflurane or continuous propofol administration. The level of thiobarbituric acid-reactive substances (TBARS) in the plasma was determined as a measure of free radicals before and after surgery. Results: Ten patients in the propofol group had reduced TBARS. as compared to only one in the isoflurane group (p = 0.003). There was a statistically significant difference in age between the patients with reduced TBARS and those without reduced TBARS (P = 0.009) in the propofol group. Conclusions: Anesthesia with continuous propofol infusion in laparoscopic surgery has a significant scavenging action on the formation of free radicals and exerts its greatest antioxidant effect in patients greater than or equal to 48 years of age.
Περιγραφή
Λέξεις-κλειδιά
laparoscopic surgery, lipid peroxidation, propofol, pneumoperitoneum, oxidative stress, antioxidant, ischemia, 2,6-diisopropylphenol, anesthesia, scavenger, increase, plasma, age
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000170773900010
http://www.springerlink.com/content/hyuh783e6gl8690u/fulltext.pdf
http://www.springerlink.com/content/hyuh783e6gl8690u/fulltext.pdf
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας