Maternal peripheral blood lymphocyte subpopulations in normal and pathological pregnancies

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dc.contributor.authorMakrydimas, G.en
dc.contributor.authorPlachouras, N.en
dc.contributor.authorHigueras, M. T.en
dc.contributor.authorThilaganathan, B.en
dc.contributor.authorNicolaides, K.en
dc.date.accessioned2015-11-24T19:05:17Z
dc.date.available2015-11-24T19:05:17Z
dc.identifier.issn1015-3837-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20173
dc.rightsDefault Licence-
dc.subjectAbortion, Missed/blooden
dc.subjectAneuploidyen
dc.subjectCD4-CD8 Ratioen
dc.subjectCD4-Positive T-Lymphocytesen
dc.subjectCD8-Positive T-Lymphocytesen
dc.subjectFemaleen
dc.subjectFetal Growth Retardation/blooden
dc.subjectFlow Cytometryen
dc.subjectHumansen
dc.subjectKiller Cells, Naturalen
dc.subjectLymphocyte Counten
dc.subject*Lymphocyte Subsetsen
dc.subjectPregnancyen
dc.subjectPregnancy Complications/*blooden
dc.subjectPregnancy, Ectopic/blooden
dc.subjectPregnancy, Multiple/blooden
dc.titleMaternal peripheral blood lymphocyte subpopulations in normal and pathological pregnanciesen
heal.abstractFlow cytometry was used to determine lymphocyte subpopulations in maternal blood from 143 pathological pregnancies: 50 with fetal aneuploidy; 32 with missed abortions; 12 with ectopic pregnancies; 20 with multi-fetal pregnancies, and 29 with pregnancies complicated by intrauterine growth retardation (IUGR). The values were compared to those of 240 women with normal singleton pregnancies at 8-40 weeks of gestation and 20 non-pregnant controls. In early pregnancy (8-10 weeks), compared to non-pregnant values, there was a decrease in the percentage of CD4+ cells and CD4+ to CD8+ ratio and an increase in the percentage of CD8+ cells. In later pregnancy, the CD4+ cell percentage and CD4+ to CD8+ ratio increased and the CD8+ cell percentage decreased to reach non-pregnant values at term. The percentage of natural killer (CD3- and CD16/56+) cells decreased with gestation, while the percentage of B (CD19+) cells did not change significantly. In IUGR, the percentage of CD4+ cells and CD4+ to CD8+ ratio were decreased, while the percentage of CD8+ cells was increased. In contrast, in the groups of missed abortions and ectopic pregnancies, the CD4+ to CD8+ ratio was increased. In multifetal pregnancies and those with fetal aneuploidies there were no significant differences in maternal lymphocyte subpopulations from normals.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/7880433-
heal.journalNameFetal Diagn Theren
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1994-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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