Somatostatin receptors in the ventral pallidum/substantia innominata modulate rat locomotor activity

Απλή σελίδα τεκμηρίου
dc.contributor.authorMarazioti, A.en
dc.contributor.authorKastellakis, A.en
dc.contributor.authorAntoniou, K.en
dc.contributor.authorPapasava, D.en
dc.contributor.authorThermos, K.en
dc.date.accessioned2015-11-24T18:51:00Z
dc.date.available2015-11-24T18:51:00Z
dc.identifier.issn0033-3158-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18191
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectDose-Response Relationship, Drugen
dc.subjectGlobus Pallidus/drug effects/*physiology/surgeryen
dc.subjectInjections, Intraventricularen
dc.subjectMaleen
dc.subjectMotor Activity/drug effects/*physiologyen
dc.subjectOligopeptides/pharmacologyen
dc.subjectPeptides, Cyclic/pharmacologyen
dc.subjectPiperazines/pharmacologyen
dc.subjectQuinolines/pharmacologyen
dc.subjectRatsen
dc.subjectRats, Sprague-Dawleyen
dc.subjectReceptors, Somatostatin/antagonists & inhibitors/*physiologyen
dc.subjectSomatostatin/administration & dosage/analogs & derivatives/pharmacologyen
dc.subjectStereotaxic Techniquesen
dc.subjectSubstantia Innominata/drug effects/*physiologyen
dc.subjectTime Factorsen
dc.titleSomatostatin receptors in the ventral pallidum/substantia innominata modulate rat locomotor activityen
heal.abstractRATIONALE: Somatostatin and its receptors (sst(1) and sst(2)) have been localized in brain nuclei implicated in motor control, such as the nucleus accumbens, ventral pallidum (VP) and substantia innominata (SI). OBJECTIVES: The objective of the study is to investigate the effect of somatostatin and selective sst(1) and sst(2) analogs infused in the VP/SI on the locomotor activity of the rat. METHODS: Somatostatin (15, 30, 60, 120 and 240 ng/0.5 microl/side), CH275 (sst(1) analog; 60, 180, 240 and 480 ng/0.5 microl/side), MK678 (sst(2) analog; 120, 240 and 480 ng/0.5 microl/side), L-809,087 (sst(4) agonist, 240 ng/0.5 microl/side) or saline (vehicle) were infused bilaterally in the VP/SI of the rat and locomotor activity measured for 60 min. The effect of SRA-880 (sst(1) antagonist) and CYN-154806 (sst(2) antagonist) on somatostatin-, CH275- and MK678-mediated locomotor activity was also ascertained. RESULTS: Somatostatin decreased locomotor activity in the first 30 min after its infusion in the VP/SI and in a dose-dependent manner. The sst(1) and sst(2) antagonists, SRA-880 and CYN-154806, respectively, reversed the somatostatin effect. The sst(1) and sst(2) agonists CH275 and MK678, respectively, mimicked somatostatin's actions, while the selective sst(4) agonist L-809,087 had no effect. Moreover, SRA-880 and CYN-154806 reversed the respective agonist action on locomotor activity. CONCLUSION: The present study provides functional evidence for the presence of sst(1) and sst(2) receptors in the VP/SI and their implication in motor control. The mechanism via which somatostatin and agonists mediate the attenuation of locomotor activity is presently being investigated.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1007/s00213-005-2237-z-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/15778878-
heal.identifier.secondaryhttp://www.springerlink.com/content/j5640gh26g026721/fulltext.pdf-
heal.journalNamePsychopharmacology (Berl)en
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2005-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

Αρχεία

Φάκελος/Πακέτο αδειών

Προβολή: 1 - 1 of 1
Μικρογραφία εικόνας
Ονομα:
license.txt
Μέγεθος:
1.74 KB
Μορφότυπο:
Item-specific license agreed upon to submission
Περιγραφή:
Κατεβάστε

Συλλογές

Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ