Embryo-fetal erythroid megaloblasts in the human coelomic cavity

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dc.contributor.authorRenda, M. C.en
dc.contributor.authorGiambona, A.en
dc.contributor.authorFecarotta, E.en
dc.contributor.authorLeto, F.en
dc.contributor.authorMakrydimas, G.en
dc.contributor.authorRenda, D.en
dc.contributor.authorDamiani, G.en
dc.contributor.authorJakil, M. C.en
dc.contributor.authorPicciotto, F.en
dc.contributor.authorPiazza, A.en
dc.contributor.authorValtieri, M.en
dc.contributor.authorMaggio, A.en
dc.date.accessioned2015-11-24T19:19:57Z
dc.date.available2015-11-24T19:19:57Z
dc.identifier.issn1097-4652-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21999
dc.rightsDefault Licence-
dc.subjectAntigens, CD/metabolismen
dc.subjectAntigens, CD45en
dc.subjectBody Fluids/*cytologyen
dc.subjectEmbryo, Mammalian/*cytology/physiologyen
dc.subjectFlow Cytometryen
dc.subjectGene Expression Regulation, Developmentalen
dc.subjectHumansen
dc.subjectMegaloblasts/*physiologyen
dc.subjectPolymerase Chain Reaction/methodsen
dc.subjectReceptors, Transferrin/metabolismen
dc.subjectYolk Sac/physiologyen
dc.subjectepsilon-Globins/genetics/metabolismen
dc.subjectgamma-Globins/genetics/metabolismen
dc.titleEmbryo-fetal erythroid megaloblasts in the human coelomic cavityen
heal.abstractThe coelomic cavity is part of the extraembryonic mesoderm, surrounding amniotic cavity, embryo, and yolk sac in the early gestation. It is now believed to represent an important transfer interface and a reservoir of nutrients for the embryo. Coelocentesis by ultrasound-guided transvaginal puncture offers an easier access to the early human embryo, from 28 days post-fertilization. However, despite some studies about its biochemical composition being reported, our knowledge about the presence of cellular elements and their quality in this compartment are still limited. Here we studied human coelomic fluids sampled from 6.6 (48 days) to 10 weeks of gestation, demonstrating the presence of functional embryonic erythroid precursors, that is, megaloblasts in the coelomic cavity. The ease of access of the coelomic cavity could allow the development of novel strategies for diagnostic or therapeutic purposes by ultrasound imaging and ultrasound-guided puncture.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1002/jcp.22269-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/20533375-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1002/jcp.22269/asset/22269_ftp.pdf?v=1&t=h0l487ke&s=a9e0daa2e6339fbd86c54d1cc3fcee23b804c406-
heal.journalNameJ Cell Physiolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2010-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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