Mechanisms of reoxygenation injury in myocardial infarction: implications of a myoglobin redox cycle
| dc.contributor.author | Galaris, D. | en |
| dc.contributor.author | Eddy, L. | en |
| dc.contributor.author | Arduini, A. | en |
| dc.contributor.author | Cadenas, E. | en |
| dc.contributor.author | Hochstein, P. | en |
| dc.date.accessioned | 2015-11-24T19:05:03Z | |
| dc.date.available | 2015-11-24T19:05:03Z | |
| dc.identifier.issn | 0006-291X | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/20135 | |
| dc.rights | Default Licence | - |
| dc.subject | Animals | en |
| dc.subject | Ascorbic Acid/pharmacology | en |
| dc.subject | Creatine Kinase/metabolism | en |
| dc.subject | Hydrogen Peroxide/metabolism | en |
| dc.subject | L-Lactate Dehydrogenase/metabolism | en |
| dc.subject | Myocardial Infarction/complications/*metabolism | en |
| dc.subject | Myocardial Reperfusion Injury/etiology/*metabolism/prevention & control | en |
| dc.subject | Myoglobin/*metabolism | en |
| dc.subject | Oxidation-Reduction | en |
| dc.subject | Rats | en |
| dc.subject | Rats, Inbred Strains | en |
| dc.subject | Spectrophotometry | en |
| dc.title | Mechanisms of reoxygenation injury in myocardial infarction: implications of a myoglobin redox cycle | en |
| heal.abstract | The addition of ascorbate to ischemic rat hearts prevents the myocardial damage associated with reoxygenation. H2O2 oxidizes myoglobin (Mb+2) to higher oxidation states (Mb+4 and Mb+5) which are rapidly reduced by ascorbate. It is proposed that the operation of a myoglobin redox cycle, in which H2O2 causes the two-electron oxidation of myoglobin, is a critical determinant of reperfusion injury. Conversely, the reduction of myoglobin, in one-electron steps, may represent an essential protective mechanism against such injury in the heart. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/2730642 | - |
| heal.identifier.secondary | http://www.sciencedirect.com/science/article/pii/S0006291X89801251 | - |
| heal.journalName | Biochem Biophys Res Commun | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1989 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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