Correlation of glioma proliferation assessed by flow cytometry with (99m)Tc-Tetrofosmin SPECT uptake

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dc.contributor.authorAlexiou, G. A.en
dc.contributor.authorTsiouris, S.en
dc.contributor.authorVartholomatos, G.en
dc.contributor.authorFotakopoulos, G.en
dc.contributor.authorPapadopoulos, A.en
dc.contributor.authorKyritsis, A. P.en
dc.contributor.authorVoulgaris, S.en
dc.contributor.authorFotopoulos, A. D.en
dc.date.accessioned2015-11-24T19:26:49Z
dc.date.available2015-11-24T19:26:49Z
dc.identifier.issn1872-6968-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22760
dc.rightsDefault Licence-
dc.subjectAgeden
dc.subjectAneuploidyen
dc.subjectBrain Neoplasms/genetics/*pathology/*radionuclide imagingen
dc.subjectCell Proliferationen
dc.subjectDNA/geneticsen
dc.subjectFemaleen
dc.subjectFlow Cytometryen
dc.subjectGamma Camerasen
dc.subjectGlioblastoma/pathology/radionuclide imagingen
dc.subjectGlioma/genetics/*pathology/*radionuclide imagingen
dc.subjectHumansen
dc.subjectImage Processing, Computer-Assisteden
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectOrganophosphorus Compounds/*diagnostic useen
dc.subjectOrganotechnetium Compounds/*diagnostic useen
dc.subjectPilot Projectsen
dc.subjectProspective Studiesen
dc.subjectRadiopharmaceuticals/*diagnostic useen
dc.subjectTomography, Emission-Computed, Single-Photonen
dc.titleCorrelation of glioma proliferation assessed by flow cytometry with (99m)Tc-Tetrofosmin SPECT uptakeen
heal.abstractOBJECTIVES: Brain single-photon emission computed tomography (SPECT) has been proposed as a potentially useful modality for the metabolic assessment of various brain tumors. MATERIAL AND METHODS: In a 10-patient prospective pilot study we evaluated whether (99m)Tc-Tetrofosmin ((99m)Tc-TF) uptake correlates with glioma proliferative activity assessed by flow cytometric analysis. (99m)Tc-TF brain SPECT was performed shortly before surgical tumor excision. RESULTS: Eight patients were diagnosed with glioblastoma multiform and 2 with anaplastic astrocytoma. All tumors were aneuploid. We found a significant positive linear correlation between (99m)Tc-TF uptake and percentage of tumor cells on the S-phase of the cell cycle (r=0.92, P=0.001). CONCLUSION: Initial evidence suggests that (99m)Tc-TF could provide a non-invasive indicator of glioma proliferative activity.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/j.clineuro.2009.08.009-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/19726126-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0303846709002121/1-s2.0-S0303846709002121-main.pdf?_tid=a4247142786b2602bfcec5ad74596eb0&acdnat=1332758399_9c9e3d3b4b12554f8a686dfed3c43b67-
heal.journalNameClin Neurol Neurosurgen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2009-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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