Luteinizing hormone pulsatility in men with damage to the germinal epithelium
Φόρτωση...
Ημερομηνία
Συγγραφείς
Talbot, J. A.
Shalet, S. M.
Tsatsoulis, A.
Grabinski, M.
Robertson, W. R.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Int J Androl
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Bioactive-LH (B-LH) was measured in plasma by in-vitro bioassay and immunoactive-LH (I-LH) by immunoassay at 10 min intervals for 6 h in five men after standard chemotherapy for Hodgkin's disease. Eleven normal men acted as controls. Follicle-stimulating hormone (FSH) was markedly raised in the treated patients (mean +/- SEM; 12.8 +/- 2.8 vs. 2.7 +/- 0.4 IU l-1, P less than 0.006) reflecting damage to the germinal epithelium. Bioactive (27.4 +/- 2.8 vs. 12.9 +/- 1.3 IU l-1) and I-LH (9.6 +/- 2.0 vs. 4.9 +/- 0.4 IU l-1) were elevated (P less than 0.006) in the patient group whilst testosterone levels (24.0 +/- 3.8 vs. 19.6 +/- 2.4 nmol l-1) were normal. The testosterone I-LH ratio, a putative index of Leydig cell dysfunction, was negatively correlated with FSH levels (r = -0.85, P less than 0.02). Bioactive and I-LH pulse peak amplitude were elevated, as were pulse maxima (P less than 0.05). In contrast, B-LH pulse frequency was similar between the patients (2 pulses per 6 h) and controls (median 2, range 1-3 pulses per 6 h) as was the I-LH pulse frequency (median 2, 1-2 pulses per 6 h in both groups). The mean B:I LH ratios were similar (2.94 +/- 0.09 vs. 2.63 +/- 0.14) in both groups, although the inter-pulse B:I ratio was increased (P less than 0.007) in the patient group.(ABSTRACT TRUNCATED AT 250 WORDS)
Περιγραφή
Λέξεις-κλειδιά
Adult, Antineoplastic Combined Chemotherapy Protocols/*adverse effects/therapeutic use, Cells, Cultured, Hodgkin Disease/*drug therapy, Humans, Leydig Cells/drug effects/*secretion, Luteinizing Hormone/*secretion, Male, Mechlorethamine/adverse effects/therapeutic use, Prednisolone/adverse effects/therapeutic use, Procarbazine/adverse effects/therapeutic use, Pulsatile Flow, Radioimmunoassay, Testosterone/blood, Vinblastine/adverse effects/therapeutic use
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/2387642
http://onlinelibrary.wiley.com/store/10.1111/j.1365-2605.1990.tb00980.x/asset/j.1365-2605.1990.tb00980.x.pdf?v=1&t=h0ouov8k&s=3c2e0ad393637e1cd3d2b261e8140195cf3016e9
http://onlinelibrary.wiley.com/store/10.1111/j.1365-2605.1990.tb00980.x/asset/j.1365-2605.1990.tb00980.x.pdf?v=1&t=h0ouov8k&s=3c2e0ad393637e1cd3d2b261e8140195cf3016e9
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής