A randomized phase III study of adjuvant platinum/docetaxel chemotherapy with or without radiation therapy in patients with gastric cancer

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dc.contributor.authorBamias, A.en
dc.contributor.authorKarina, M.en
dc.contributor.authorPapakostas, P.en
dc.contributor.authorKostopoulos, I.en
dc.contributor.authorBobos, M.en
dc.contributor.authorVourli, G.en
dc.contributor.authorSamantas, E.en
dc.contributor.authorChristodoulou, Chen
dc.contributor.authorPentheroudakis, G.en
dc.contributor.authorPectasides, D.en
dc.contributor.authorDimopoulos, M. A.en
dc.contributor.authorFountzilas, G.en
dc.date.accessioned2015-11-24T19:39:27Z
dc.date.available2015-11-24T19:39:27Z
dc.identifier.issn1432-0843-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24247
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAntineoplastic Combined Chemotherapy Protocols/adverse effects/*therapeutic useen
dc.subjectCarboplatin/administration & dosage/adverse effectsen
dc.subjectChemotherapy, Adjuvanten
dc.subjectCisplatin/administration & dosage/adverse effectsen
dc.subjectCombined Modality Therapyen
dc.subjectDiarrhea/chemically induceden
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subjectKaplan-Meier Estimateen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectNeutropenia/chemically induceden
dc.subjectPrognosisen
dc.subjectReceptor, Epidermal Growth Factor/analysisen
dc.subjectReceptor, erbB-2/analysisen
dc.subjectStomach Neoplasms/*drug therapy/metabolism/pathology/*radiotherapyen
dc.subjectTaxoids/administration & dosage/adverse effectsen
dc.subjectTissue Array Analysisen
dc.subjectTreatment Outcomeen
dc.subjectTumor Markers, Biological/analysisen
dc.titleA randomized phase III study of adjuvant platinum/docetaxel chemotherapy with or without radiation therapy in patients with gastric canceren
heal.abstractThe optimal adjuvant treatment for gastric cancer remains controversial. We compared the efficacy of a docetaxel and platinum adjuvant chemotherapy regimen, in patients with high-risk gastric cancer, with that of the same chemotherapy plus radiation therapy (RT). In addition, we evaluated the prognostic and/or predictive value of a panel of molecular markers. Patients with histologically proven, radically resected gastric cancer, stage > or =T3 and/or N+ were randomized to 6 cycles of docetaxel with cisplatin, both at 75 mg/m2 every 3 weeks (arm A) or the same treatment with RT (arm B; 45 Gy). Due to excessive nausea and vomiting, cisplatin was substituted by carboplatin at AUC (area under the curve) of 5 after the first 45 patients (22 group A, 23 group B). The prognostic value of EGFR, ERCC1, HER2, MET/HGFR, MAP-Tau, and PTEN expression was also studied in a subset of 67 patients using immunohistochemistry on tissue microarrays (TMAs). A total of 147 patients were randomized. After a median follow-up of 53.7 months, no differences in overall (OS) and disease-free survival (DFS) were found between the two arms. The most common grade 3/4 toxicities for arms A and B (excluding alopecia) were non-febrile neutropenia (11 and 17%, respectively), febrile neutropenia (9 and 7%) and diarrhea (7 and 4%, respectively). Patients with ERCC1 positive tumors had significantly longer median DFS (33.1 vs. 11.8 months, Wald P = 0.016) and OS (63.2 vs. 18.8 months, Wald P = 0.046). Our results indicate that the addition of RT to platinum/docetaxel adjuvant chemotherapy does not appear to improve survival in high-risk, radically resected gastric cancer. However, the possibility that a benefit by the addition of RT was not detected due to decreased power of the study should not be excluded.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1007/s00280-010-1256-6-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/20130877-
heal.identifier.secondaryhttp://www.springerlink.com/content/q3r40k344751232t/fulltext.pdf-
heal.journalNameCancer Chemother Pharmacolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2010-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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