Pioglitazone vs glimepiride: Differential effects on vascular endothelial function in patients with type 2 diabetes

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dc.contributor.authorPapathanassiou, K.en
dc.contributor.authorNaka, K. K.en
dc.contributor.authorKazakos, N.en
dc.contributor.authorKanioglou, C.en
dc.contributor.authorMakriyiannis, D.en
dc.contributor.authorPappas, K.en
dc.contributor.authorKatsouras, C. S.en
dc.contributor.authorLiveris, K.en
dc.contributor.authorKolettis, T.en
dc.contributor.authorTsatsoulis, A.en
dc.contributor.authorMichalis, L. K.en
dc.date.accessioned2015-11-24T18:58:24Z
dc.date.available2015-11-24T18:58:24Z
dc.identifier.issn1879-1484-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19275
dc.rightsDefault Licence-
dc.subjectAgeden
dc.subjectBlood Glucose/metabolismen
dc.subjectDiabetes Mellitus, Type 2/*drug therapyen
dc.subjectEndothelium, Vascular/*drug effectsen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectHypoglycemic Agents/therapeutic useen
dc.subjectInsulin Resistanceen
dc.subjectMaleen
dc.subjectMetformin/therapeutic useen
dc.subjectMiddle Ageden
dc.subjectSulfonylurea Compounds/*therapeutic useen
dc.subjectThiazolidinediones/*therapeutic useen
dc.subjectTreatment Outcomeen
dc.titlePioglitazone vs glimepiride: Differential effects on vascular endothelial function in patients with type 2 diabetesen
heal.abstractOBJECTIVE: The aim of this study was to compare the effect of glimepiride and pioglitazone on endothelial function in patients with type 2 diabetes already on metformin. METHODS: Twenty-eight patients with type 2 diabetes already on metformin, without known cardiovascular disease, were randomized in 2 groups; glimepiride (4 mg od) was added in group A (n=14) and pioglitazone (30 mg od) in group B (n=14) for 6 months. Flow-mediated dilation (FMD) in the brachial artery was assessed in all patients, at baseline and at follow-up. RESULTS: The 2 groups did not differ in age (mean+/-S.D., 63.6+/-7.3 years vs 62.8+/-7.2 years respectively), or any measured variable at baseline. Fasting glucose and glycated haemoglobin improved similarly in both groups. There were significant differences between the 2 groups in the absolute changes observed at follow-up in waist circumference, +1.86+/-3.11 cm vs -1.86+/-1.88 cm in groups A and B respectively; fasting insulin levels, +14.79+/-12.56 pmol/L vs -25.84+/-28.09 pmol/L; homeostasis model assessment (HOMA), +0.66+/-1.01 vs -1.83+/-1.38; HDL cholesterol levels, -0.07+/-0.22 mmol/L vs +0.14+/-0.20 mmol/L and FMD, +0.14+/-1.09% vs +2.02+/-2.05% (p<0.05 for all). The only independent predictor factor of the FMD improvement was treatment-induced changes in HOMA (R(2): 0.488, slope: -0.782, [95% CI: -1.128, -0.436], p=0.0001). CONCLUSIONS: In patients with type 2 diabetes already on metformin, addition of pioglitazone as compared to glimepiride, improved endothelial function despite similar glycemic control. The improvement in endothelial function was mainly due to a reduction in insulin resistance.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/j.atherosclerosis.2008.11.027-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/19135671-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0021915008008411/1-s2.0-S0021915008008411-main.pdf?_tid=432e7f32fe766702610c0511a746e1ae&acdnat=1333969737_a0ef08da311b591d5bd9216ef71f05cf-
heal.journalNameAtherosclerosisen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2009-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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