Immunohistochemical expression of Bcl-2 protein in breast lesions: correlation with Bax, p53, Rb, C-erbB-2, EGFR and proliferation indices

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dc.contributor.authorIoachim, E. E.en
dc.contributor.authorMalamou-Mitsi, V.en
dc.contributor.authorKamina, S. A.en
dc.contributor.authorGoussia, A. C.en
dc.contributor.authorAgnantis, N. J.en
dc.date.accessioned2015-11-24T19:12:00Z
dc.date.available2015-11-24T19:12:00Z
dc.identifier.issn0250-7005-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20996
dc.rightsDefault Licence-
dc.subjectBreast/chemistryen
dc.subjectBreast Neoplasms/*chemistryen
dc.subjectCarcinoma, Ductal, Breast/chemistryen
dc.subjectCarcinoma, Lobular/chemistryen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subjectKi-67 Antigen/analysisen
dc.subjectMiddle Ageden
dc.subjectNeoplasm Proteins/*analysisen
dc.subjectProliferating Cell Nuclear Antigen/analysisen
dc.subjectProto-Oncogene Proteins/analysisen
dc.subjectProto-Oncogene Proteins c-bcl-2/*analysisen
dc.subjectReceptor, Epidermal Growth Factor/analysisen
dc.subjectReceptor, erbB-2/analysisen
dc.subjectRetinoblastoma Protein/analysisen
dc.subjectTumor Suppressor Protein p53/analysisen
dc.subjectbcl-2-Associated X Proteinen
dc.titleImmunohistochemical expression of Bcl-2 protein in breast lesions: correlation with Bax, p53, Rb, C-erbB-2, EGFR and proliferation indicesen
heal.abstractExpression of bcl-2 protein was investigated and correlated with Bax, p53 and Rb proteins, c-erbB-2, EGFR and the proliferation indices PCNA, Ki-67 and MIB1 as well as with the conventional clinicopathological parameters in 95 cases for breast cancer tissue and 20 cases of benign hyperplastic lesions. Bcl-2 and Bax proteins immunoreactivity was detected in normal, hyperplastic and neoplastic breast epithelium. Expression of the bcl-2 protein was detected in 40% of carcinomas (> 10% positive neoplastic cells) and 85.2% of the benign hyperplastic lesions. Bax protein expression was detected in 8.1% of the carcinomas and 5.3% in the hyperplastic group. Rb and p53 proteins were detected in 75.5% and 45.5% of carcinomas. No relationship was observed between bcl-2 expression and patient's age, tumour size, tumour type and grade, lymph node status, Rb protein expression and proliferation indices. However, a strong positive relationship was detected between bcl-2 and Bax (p = 0.008), estrogen (ER) (p = 0.007) and progesterone receptors' (PgR) status (p = 0.0003). An inverse correlation with p53 protein (p = 0.004) was detected. Furthermore, a strong correlation was also observed between pRb and p53 (p = 0.001). The results indicate that in breast cancer bcl-2 protein expression may be under hormonal control. Since the expression is bcl-2 protein was inversely correlated with p53 protein expression, we suggest that bcl-2 may be related with favourable outcome in breast cancer.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/11205251-
heal.journalNameAnticancer Resen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2000-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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