Synthesis, characterization and biological studies of new antimony(III) halide complexes with omega-thiocaprolactam

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dc.contributor.authorOzturk, I. I.en
dc.contributor.authorBanti, C. N.en
dc.contributor.authorManos, M. J.en
dc.contributor.authorTasiopoulos, A. J.en
dc.contributor.authorKourkoumelis, N.en
dc.contributor.authorCharalabopoulos, K.en
dc.contributor.authorHadjikakou, S. K.en
dc.date.accessioned2015-11-24T16:49:24Z
dc.date.available2015-11-24T16:49:24Z
dc.identifier.issn0162-0134-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/9481
dc.rightsDefault Licence-
dc.subjectbioinorganic chemistryen
dc.subjectantimony(iii) halide complexesen
dc.subjectomega-thiocaprolactamen
dc.subjectcrystal structuresen
dc.subjectcytotoxic activityen
dc.subjectstructural-characterizationen
dc.subjecttriphenylphosphineen
dc.subjectthioamidesen
dc.subjectligandsen
dc.subjectorganotin(iv)en
dc.subjectlipoxygenaseen
dc.subjectoncologyen
dc.subjectthionesen
dc.subjectaciden
dc.subjectbren
dc.titleSynthesis, characterization and biological studies of new antimony(III) halide complexes with omega-thiocaprolactamen
heal.abstractThree new antimony(III) halide complexes (SbX3, X = Cl, Br and I) with the heterocyclic thione omega-thiocaprolactam (1-azacycloheptane-2-thione, (Hthcl)) of formulae {[SbCl2(mu(2)-Cl)(Hthcl)(2)](n)} (1), {[(SbBr2(mu(2)-Br)(Hthcl)(2))(2)]} (2) and {[(Sbl(2)(mu(2)-I)(Hthcl)(2))(2)]} (3) were synthesized from the reaction of antimony(III) halides with w-thiocaprolactam in 1:2 stoichiometry. The complexes were characterized by elemental analysis, FT-IR spectroscopy, H-1, C-13 NMR spectroscopy and Thermal Gravimetry-Differential Thermal Analysis (TG-DTA). Crystal structures of the ligand w-thiocaprolactam and its complexes 1-3 were determined with single crystal X-ray diffraction analysis. Complexes 1-3 and w-thiocaprolactam were evaluated for their in vitro cytotoxic activity against leiomyosarcoma (LMS) and human breast adenocarcinoma (MCF-7) tumor cell lines. Antimony complexes 1-3 exhibit strong antiproliferative activity against both cell lines tested. The higher such activity was found for 3 with IC50 values of 0.12 +/- 0.04 mu M (LMS) and 0.76 +/- 0.16 mu M (MCF-7) which are 60 and 10 times respectively, stronger than that of cisplatin. The influence of these complexes 1-3 and w-thiocaprolactam upon the catalytic peroxidation of linoleic acid to hyperoxolinoleic acid by the enzyme lipoxygenase (LOX) was kinetically and theoretically studied. The results were shown negligible inhibitory activity of 1-3 against LOX. (C) 2012 Elsevier Inc. All rights reserved.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDOI 10.1016/j.jinorgbio.2012.01.014-
heal.identifier.secondary<Go to ISI>://000303178200008-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0162013412000414/1-s2.0-S0162013412000414-main.pdf?_tid=50ba3762-3636-11e3-9c95-00000aab0f6b&acdnat=1381909446_8914026033fcdf11e1749f05472b907e-
heal.journalNameJ Inorg Biochemen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2012-
heal.publisherElsevieren
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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