Serum adipocytokine and vascular inflammation marker levels in Beta-thalassaemia major patients
Φόρτωση...
Ημερομηνία
Συγγραφείς
Chaliasos, N.
Challa, A.
Hatzimichael, E.
Koutsouka, F.
Bourantas, D.
Vlahos, A. P.
Siamopoulou, A.
Bourantas, K. L.
Makis, A.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Acta Haematol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
BACKGROUND/AIM: The adipocytokines leptin and adiponectin represent a critical link between metabolism, immunity and chronic inflammation. A chronic vascular inflammatory state plays an important role in the pathophysiology of thalassaemia. We aimed to analyze the levels of these adipocytokines and determine any possible correlations with disease severity or vascular inflammation markers in beta-thalassaemia. METHODS: Serum leptin, adiponectin, high-sensitivity C-reactive protein, endothelins, vascular adhesion molecule-1, intracellular adhesion molecule-1 and L- and E-selectin were measured in 28 beta-thalassaemia patients and compared with levels in healthy controls. RESULTS: Leptin was significantly lower in patients compared to controls (2.23 +/- 1.8 vs. 10.24 +/- 5.78 mug/l; p = 0.0018), whereas adiponectin was elevated (11.75 +/- 5.67 vs. 6.83 +/- 2.75 mug/l; p = 0.009). For both adipocytokines, no correlations were found with characteristics such as age, gender, type of chelation, body mass index z score or haemoglobin. Leptin, but not adiponectin, was negatively correlated with ferritin (p = 0.032, r = -0.61). No correlations were found between leptin and the inflammation markers. However, adiponectin was positively correlated with endothelin-1 (p = 0.022, r = 0.63). CONCLUSIONS: Serum leptin is low in beta-thalassaemia, perhaps due to the toxic effect of iron overload on adipose tissue. Paradoxically, adiponectin levels are high and positively correlated with endothelin-1, raising questions about the pro- or anti-inflammatory role of this adipocytokine in beta-thalassaemia.
Περιγραφή
Λέξεις-κλειδιά
Adipokines/*blood, Adiponectin/*blood, Adolescent, Adult, Aging, Biological Markers/blood, Blood Transfusion, Body Mass Index, C-Reactive Protein/metabolism, Chelating Agents/therapeutic use, Child, Endothelin-1/blood, Endothelin-3/blood, Female, Ferritins/blood, Humans, Inflammation/*blood, Intercellular Adhesion Molecule-1/blood, Leptin/blood, Male, Middle Aged, Vascular Cell Adhesion Molecule-1/blood, beta-Thalassemia/*blood/drug therapy/genetics/immunology
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/21042009
http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowPDF&ArtikelNr=000320274&Ausgabe=254671&ProduktNr=223829&filename=000320274.pdf
http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowPDF&ArtikelNr=000320274&Ausgabe=254671&ProduktNr=223829&filename=000320274.pdf
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής