Corticotropin-releasing hormone promotes blastocyst implantation and early maternal tolerance

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dc.contributor.authorMakrigiannakis, A.en
dc.contributor.authorZoumakis, E.en
dc.contributor.authorKalantaridou, S.en
dc.contributor.authorCoutifaris, C.en
dc.contributor.authorMargioris, A. N.en
dc.contributor.authorCoukos, G.en
dc.contributor.authorRice, K. C.en
dc.contributor.authorGravanis, A.en
dc.contributor.authorChrousos, G. P.en
dc.date.accessioned2015-11-24T19:26:35Z
dc.date.available2015-11-24T19:26:35Z
dc.identifier.issn1529-2908-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22741
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectAntigens, CD95/physiologyen
dc.subjectApoptosis/drug effectsen
dc.subjectBlastocyst/immunology/*physiologyen
dc.subjectCells, Cultured/drug effects/metabolismen
dc.subjectCorticotropin-Releasing Hormone/pharmacology/*physiologyen
dc.subjectDecidua/immunologyen
dc.subjectEmbryo Implantation/drug effects/*physiologyen
dc.subjectEndometrium/immunology/*metabolismen
dc.subjectFas Ligand Proteinen
dc.subjectFemaleen
dc.subjectGene Expression Regulation/drug effectsen
dc.subjectHistocompatibilityen
dc.subjectHumansen
dc.subjectInflammationen
dc.subjectLitter Size/drug effectsen
dc.subjectMembrane Glycoproteins/biosynthesis/geneticsen
dc.subjectPregnancyen
dc.subjectPyrimidines/pharmacology/toxicityen
dc.subjectPyrroles/pharmacology/toxicityen
dc.subjectRatsen
dc.subjectRats, Inbred F344en
dc.subjectRats, Nudeen
dc.subjectRats, Sprague-Dawleyen
dc.subjectReceptors, Corticotropin-Releasing Hormone/antagonists & inhibitors/physiologyen
dc.subjectT-Lymphocyte Subsets/drug effects/immunologyen
dc.subjectTrophoblasts/immunologyen
dc.titleCorticotropin-releasing hormone promotes blastocyst implantation and early maternal toleranceen
heal.abstractThe semi-allograft embryo in the blastocyst stage implants itself in the endometrium, yet no immune rejection processes are activated. Embryonic trophoblast and maternal decidua produce corticotropin-releasing hormone (CRH) and express Fas ligand (FasL), a proapoptotic cytokine. We found that antalarmin, a CRH receptor type 1 antagonist, decreased FasL expression and promoted apoptosis of activated T lymphocytes, an effect which was potentiated by CRH and inhibited by antalarmin. Female rats treated with antalarmin showed a marked decrease in implantation sites and live embryos and diminished endometrial FasL expression. Embryos from mothers that lacked T cells or from syngeneic matings were not rejected when the mothers were given antalarmin. These findings suggested that locally produced CRH promotes implantation and maintenance of early pregnancy primarily by killing activated T cells.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1038/ni719-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/11590404-
heal.journalNameNat Immunolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2001-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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