Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22

Απλή σελίδα τεκμηρίου
dc.contributor.authorEvangelou, E.en
dc.contributor.authorValdes, A. M.en
dc.contributor.authorKerkhof, H. J.en
dc.contributor.authorStyrkarsdottir, U.en
dc.contributor.authorZhu, Y.en
dc.contributor.authorMeulenbelt, I.en
dc.contributor.authorLories, R. J.en
dc.contributor.authorKarassa, F. B.en
dc.contributor.authorTylzanowski, P.en
dc.contributor.authorBos, S. D.en
dc.contributor.authorAkune, T.en
dc.contributor.authorArden, N. K.en
dc.contributor.authorCarr, A.en
dc.contributor.authorChapman, K.en
dc.contributor.authorCupples, L. A.en
dc.contributor.authorDai, J.en
dc.contributor.authorDeloukas, P.en
dc.contributor.authorDoherty, M.en
dc.contributor.authorDoherty, S.en
dc.contributor.authorEngstrom, G.en
dc.contributor.authorGonzalez, A.en
dc.contributor.authorHalldorsson, B. V.en
dc.contributor.authorHammond, C. L.en
dc.contributor.authorHart, D. J.en
dc.contributor.authorHelgadottir, H.en
dc.contributor.authorHofman, A.en
dc.contributor.authorIkegawa, S.en
dc.contributor.authorIngvarsson, T.en
dc.contributor.authorJiang, Q.en
dc.contributor.authorJonsson, H.en
dc.contributor.authorKaprio, J.en
dc.contributor.authorKawaguchi, H.en
dc.contributor.authorKisand, K.en
dc.contributor.authorKloppenburg, M.en
dc.contributor.authorKujala, U. M.en
dc.contributor.authorLohmander, L. S.en
dc.contributor.authorLoughlin, J.en
dc.contributor.authorLuyten, F. P.en
dc.contributor.authorMabuchi, A.en
dc.contributor.authorMcCaskie, A.en
dc.contributor.authorNakajima, M.en
dc.contributor.authorNilsson, P. M.en
dc.contributor.authorNishida, N.en
dc.contributor.authorOllier, W. E.en
dc.contributor.authorPanoutsopoulou, K.en
dc.contributor.authorvan de Putte, T.en
dc.contributor.authorRalston, S. H.en
dc.contributor.authorRivadeneira, F.en
dc.contributor.authorSaarela, J.en
dc.contributor.authorSchulte-Merker, S.en
dc.contributor.authorShi, D.en
dc.contributor.authorSlagboom, P. E.en
dc.contributor.authorSudo, A.en
dc.contributor.authorTamm, A.en
dc.contributor.authorThorleifsson, G.en
dc.contributor.authorThorsteinsdottir, U.en
dc.contributor.authorTsezou, A.en
dc.contributor.authorWallis, G. A.en
dc.contributor.authorWilkinson, J. M.en
dc.contributor.authorYoshimura, N.en
dc.contributor.authorZeggini, E.en
dc.contributor.authorZhai, G.en
dc.contributor.authorZhang, F.en
dc.contributor.authorJonsdottir, I.en
dc.contributor.authorUitterlinden, A. G.en
dc.contributor.authorFelson, D. T.en
dc.contributor.authorvan Meurs, J. B.en
dc.contributor.authorStefansson, K.en
dc.contributor.authorIoannidis, J. P.en
dc.contributor.authorSpector, T. D.en
dc.date.accessioned2015-11-24T19:04:44Z
dc.date.available2015-11-24T19:04:44Z
dc.identifier.issn1468-2060-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20093
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectChromosomes, Human, Pair 7/*geneticsen
dc.subjectFemaleen
dc.subjectGene Expression Profiling/methodsen
dc.subject*Genetic Predisposition to Diseaseen
dc.subjectGenome-Wide Association Studyen
dc.subjectGenotypeen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectOsteoarthritis, Knee/*geneticsen
dc.subjectPhenotypeen
dc.subjectPolymorphism, Single Nucleotideen
dc.subjectYoung Adulten
dc.titleMeta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22en
heal.abstractOBJECTIVES: Osteoarthritis (OA) is the most prevalent form of arthritis and accounts for substantial morbidity and disability, particularly in older people. It is characterised by changes in joint structure, including degeneration of the articular cartilage, and its aetiology is multifactorial with a strong postulated genetic component. METHODS: A meta-analysis was performed of four genome-wide association (GWA) studies of 2371 cases of knee OA and 35 909 controls in Caucasian populations. Replication of the top hits was attempted with data from 10 additional replication datasets. RESULTS: With a cumulative sample size of 6709 cases and 44 439 controls, one genome-wide significant locus was identified on chromosome 7q22 for knee OA (rs4730250, p=9.2 x 10), thereby confirming its role as a susceptibility locus for OA. CONCLUSION: The associated signal is located within a large (500 kb) linkage disequilibrium block that contains six genes: PRKAR2B (protein kinase, cAMP-dependent, regulatory, type II, beta), HPB1 (HMG-box transcription factor 1), COG5 (component of oligomeric golgi complex 5), GPR22 (G protein-coupled receptor 22), DUS4L (dihydrouridine synthase 4-like) and BCAP29 (B cell receptor-associated protein 29). Gene expression analyses of the (six) genes in primary cells derived from different joint tissues confirmed expression of all the genes in the joint environment.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1136/ard.2010.132787-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/21068099-
heal.identifier.secondaryhttp://ard.bmj.com/content/70/2/349-
heal.journalNameAnn Rheum Disen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2011-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

Αρχεία

Φάκελος/Πακέτο αδειών

Προβολή: 1 - 1 of 1
Μικρογραφία εικόνας
Ονομα:
license.txt
Μέγεθος:
1.74 KB
Μορφότυπο:
Item-specific license agreed upon to submission
Περιγραφή:
Κατεβάστε

Συλλογές

Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ