DNA interaction studies and evaluation of biological activity of homo- and hetero-trihalide mononuclear Cu(II) Schiff base complexes. Quantitative structure-activity relationships

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dc.contributor.authorChaviara, A. T.en
dc.contributor.authorKioseoglou, E. E.en
dc.contributor.authorPantazaki, A. A.en
dc.contributor.authorTsipis, A. C.en
dc.contributor.authorKaripidis, P. A.en
dc.contributor.authorKyriakidis, D. A.en
dc.contributor.authorBolos, C. A.en
dc.date.accessioned2015-11-24T16:56:29Z
dc.date.available2015-11-24T16:56:29Z
dc.identifier.issn0162-0134-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/10446
dc.rightsDefault Licence-
dc.subjecttrihalidesen
dc.subjectschiff baseen
dc.subjectcopper(ii)en
dc.subjectDNA interactionen
dc.subjectantimicrobial studiesen
dc.subjectqsaren
dc.subjectdften
dc.subjectcrystal-structureen
dc.subjectcopper(ii) complexesen
dc.subjectcoordination-compoundsen
dc.subjectoxidative cleavageen
dc.subjecthypochlorous aciden
dc.subjectcu-iien
dc.subjectbindingen
dc.subjectnucleotidesen
dc.subjectplatinumen
dc.subjectligandsen
dc.titleDNA interaction studies and evaluation of biological activity of homo- and hetero-trihalide mononuclear Cu(II) Schiff base complexes. Quantitative structure-activity relationshipsen
heal.abstractA new series of mixed-ligand mono- or hetero-trihalide Cu(II) complexes of the type [Cu(dienXX)Y(YZ(2))] where dienXX = Schiff dibase of diethylenetriamine with 2-thiophene-carboxaldehyde (dienSS), 2-furaldehyde (dienOO) or 2-pyrrole-2-carboxaldehyde (dienNN), Y = Cl, Br and Z = Br, I was synthesized by the reaction of the precursors of the type [Cu(dienXX)Y]Y with iodine or bromine in 1:1 molar ratio. The distorted square pyramidal configuration of the new homo- and hetero-trihalide Cu(II) mononuclear complexes was identified by C. H, N, Cu analysis, spectroscopic methods (IR, UV-visible), molar conductivity and magnetic measurements. The basal plane consists of three nitrogen atoms of the Schiff base and one halogen (terminal) atom while another axially located trihalogen moiety occupies the fifth side of the square pyramid as a YZ(2) entity, adopting an almost linear configuration. The equilibrium geometry of these complexes was further corroborated by theoretical studies at the B3LYP/DGDZVP level. A series of quantum chemical descriptors (e.g. SOMO (singly occupied molecular orbital) LUMO (lowest occupied molecular orbital), SOMO and LUMO energies, SOMO-LUMO gap, dipole moment, polarizability, molar volume, etc.) have been utilized in order to deduce quantitative structure-activity relationships (QSARs). The effect of the new compounds on the single stranded (ss), double stranded (ds) and pDNA led either to the formation of a DNA-complex cationic adduct, or to its degradation, evidenced by DNA electrophoretic mobility and DNA interaction spectroscopic titration studies. Moreover, the antimicrobial activity of Cu(II) complexes against Gram(+) and Gram(-) bacteria can be attributed to the synergistic action of the dissociation species, namely the cationic [Cu(dienXX)Y](+) and anionic [YZ(2)](-) ones. Finally, de Novo linear regression analysis correlating the bioactivity of these complexes with their structural substituents has been carried out, leading to some interesting qualitative observations/conclusions. (C) 2008 Elsevier Inc. All rights reserved.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDOI 10.1016/j.jinorgbio.2008.05.005-
heal.identifier.secondary<Go to ISI>://000258637600008-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0162013408001268/1-s2.0-S0162013408001268-main.pdf?_tid=c1da74a643c70211cade6f281d1982db&acdnat=1333113012_375467d95e1b83756773fb8c1515463e-
heal.journalNameJ Inorg Biochemen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2008-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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