Prognostic impact of lymphangiogenesis and lymphatic invasion (CD105 expression) in small cell lung carcinoma

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dc.contributor.authorHardavella, G.en
dc.contributor.authorArkoumani, E.en
dc.contributor.authorDalavanga, Y.en
dc.contributor.authorGalanis, P.en
dc.contributor.authorAgnantis, N. J.en
dc.contributor.authorConstantopoulos, S.en
dc.contributor.authorStefanou, D.en
dc.date.accessioned2015-11-24T18:56:18Z
dc.date.available2015-11-24T18:56:18Z
dc.identifier.issn0250-7005-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19018
dc.rightsDefault Licence-
dc.subjectAgeden
dc.subjectAntigens, CD/*biosynthesisen
dc.subjectCarcinoma, Small Cell/blood supply/*metabolism/*pathologyen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectImmunohistochemistryen
dc.subjectLung Neoplasms/blood supply/*metabolism/*pathologyen
dc.subjectLymphangiogenesisen
dc.subjectLymphatic Metastasisen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectNeoplasm Stagingen
dc.subjectPrognosisen
dc.subjectReceptors, Cell Surface/*biosynthesisen
dc.subjectRetrospective Studiesen
dc.titlePrognostic impact of lymphangiogenesis and lymphatic invasion (CD105 expression) in small cell lung carcinomaen
heal.abstractBACKGROUND: Lymphangiogenesis, an essential process in the metastasis of malignant tumors, has not been thoroughly studied. The possibility of using it to define subsets of patients with different prognosis in cancer could be of vital clinical importance. MATERIALS AND METHODS: Fifty patients (5 women, 45 men; mean age, 64.47 years) with SCLC were retrospectively studied. Tumor specimens were stained for CD105, and intratumoral lymphatic microvessel density (ILMVD) and lymphatic invasion were determined. RESULTS: Twenty-five patients were diagnosed with limited and 25 with extensive SCLC. All patients received chemotherapy and 32.7% radiation therapy. A direct association between ILMVD (CD105 expression) and lymphatic invasion was observed (p<0.046). CD105 expression was significantly associated with the stage of the disease (p=0.004) and the presence of metastasis (p=0.05). CONCLUSION: CD105 expression and lymphatic invasion correlated significantly with the clinical parameters and patient outcome, therefore, constituting an important prognostic role in SCLC.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/18383867-
heal.journalNameAnticancer Resen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2008-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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