Proteome analysis of bronchoalveolar lavage in individuals from Metsovo, nonoccupationally exposed to asbestos

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dc.contributor.authorArchimandriti, D. T.en
dc.contributor.authorDalavanga, Y. A.en
dc.contributor.authorCianti, R.en
dc.contributor.authorBianchi, L.en
dc.contributor.authorManda-Stachouli, C.en
dc.contributor.authorArmini, A.en
dc.contributor.authorKoukkou, A. I.en
dc.contributor.authorRottoli, P.en
dc.contributor.authorConstantopoulos, S. H.en
dc.contributor.authorBini, L.en
dc.date.accessioned2015-11-24T18:55:53Z
dc.date.available2015-11-24T18:55:53Z
dc.identifier.issn1535-3893-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18948
dc.rightsDefault Licence-
dc.subjectAsbestos/*adverse effectsen
dc.subjectBronchoalveolar Lavage Fluid/*chemistryen
dc.subjectCluster Analysisen
dc.subjectGreeceen
dc.subjectHumansen
dc.subject*Mesothelioma/chemistry/etiologyen
dc.subjectMolecular Sequence Dataen
dc.subjectPleural Diseases/*etiologyen
dc.subjectProteins/*analysisen
dc.subjectProteome/*analysisen
dc.titleProteome analysis of bronchoalveolar lavage in individuals from Metsovo, nonoccupationally exposed to asbestosen
heal.abstractInhabitants of Metsovo, NW Greece, have been exposed to an asbestos whitewash, resulting in malignant pleural mesothelioma (MPM) and pleural calcifications (PCs). Interestingly, those with PCs (PC(+)) are less prone to MPM. They also have lymphocytic alveolitis, and differences in bronchoalveolar lavage (BAL) proteins, compared with those without pleural calcifications (PC(-)). This may mean a different response to the fiber leading to different susceptibility to neoplasia. To further evaluate this, a proteomic analysis of BAL proteins was performed. Proteomic analysis (2D-electrophoresis/Mass Spectrometry) of BAL in Metsovites nonoccupationally exposed to asbestos revealed increased albumin fragments, alpha1-antitrypsin, S100-A9 and HSP27, suggesting ongoing inflammation. In those without pleural calcifications, increased expression of acid ceramidase, glutathione-S-transferase and presence of calcyphosin, all involved in cell cycle regulation and death as well as in the detoxification of mutagenic and toxic agents, lend further support to our thesis of possible "protection against neoplasia" in Metsovites with pleural calcifications.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1021/pr800370n-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/19105609-
heal.identifier.secondaryhttp://pubs.acs.org/doi/abs/10.1021/pr800370n-
heal.journalNameJ Proteome Resen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2009-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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