Comparison of the efficacy of atorvastatin and micronized fenofibrate in the treatment of mixed hyperlipidemia

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dc.contributor.authorBairaktari, E. T.en
dc.contributor.authorTzallas, C. S.en
dc.contributor.authorTsimihodimos, V. K.en
dc.contributor.authorLiberopoulos, E. N.en
dc.contributor.authorMiltiadous, G. A.en
dc.contributor.authorElisaf, M. S.en
dc.date.accessioned2015-11-24T19:28:20Z
dc.date.available2015-11-24T19:28:20Z
dc.identifier.issn1350-6277-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22889
dc.rightsDefault Licence-
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAgeden
dc.subjectBiological Markers/blooden
dc.subjectCholesterol, HDL/blooden
dc.subjectCholesterol, LDL/blooden
dc.subjectFemaleen
dc.subjectFenofibrate/*therapeutic useen
dc.subjectFibrinogen/metabolismen
dc.subjectFollow-Up Studiesen
dc.subjectHeptanoic Acids/*therapeutic useen
dc.subjectHumansen
dc.subjectHydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic useen
dc.subjectHyperlipidemias/blood/*drug therapyen
dc.subjectHypolipidemic Agents/*therapeutic useen
dc.subjectLipoprotein(a)/blooden
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPyrroles/*therapeutic useen
dc.subjectTreatment Outcomeen
dc.subjectTriglycerides/blooden
dc.titleComparison of the efficacy of atorvastatin and micronized fenofibrate in the treatment of mixed hyperlipidemiaen
heal.abstractOBJECTIVE: To evaluate and compare the influences of micronized fenofibrate and atorvastatin on serum lipid profile, including lipoprotein(a) levels, and on fibrinogen levels in a large group of patients with primary mixed hyperlipidemia (serum total and low-density lipoprotein cholesterol levels > 240 and 160 mg/dl, respectively, and serum triglyceride level > 200 mg/dl). METHODS: This was a 16-week, open-label, parallel-design study conducted in our lipid clinic. After a 6-week dietary baseline phase, we implemented a treatment phase, during which patients received 10 mg/day atorvastatin (n = 45) or 200 mg/day micronized fenofibrate (n = 46) for 16 weeks. Patients were assigned to one of the drugs in sequential orders. Serum lipid profiles, including levels of lipoprotein(a) and fibrinogen, as well as muscle and liver enzymes, were measured during screening, and during weeks -4, -2, 0, 8, and 16 of the treatment period. RESULTS: Atorvastatin was more effective than was micronized fenofibrate at lowering levels of total and low-density lipoprotein cholesterol, whereas fenofibrate was more effective at lowering levels of triglycerides, and raising levels of high-density lipoprotein cholesterol and apolipoprotein A1. However, micronized fenofibrate could significantly decrease plasma fibrinogen levels, whereas atorvastatin evoked a small increase. CONCLUSION: Both atorvastatin in small doses and micronized fenofibrate are effective for improving serum lipid profiles of patients with mixed hyperlipidemia. However, there are considerable differences between the two drugs concerning their influences on plasma fibrinogen levels.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/10353071-
heal.journalNameJ Cardiovasc Risken
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1999-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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