Sarcoidosis associated with interferon-alpha therapy for chronic hepatitis C

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dc.contributor.authorPapaioannides, D.en
dc.contributor.authorFotinou, M.en
dc.contributor.authorKorantzopoulos, P.en
dc.contributor.authorLatsi, P.en
dc.contributor.authorSinapidis, D.en
dc.contributor.authorAkritidis, N.en
dc.contributor.authorOrphanidou, D.en
dc.date.accessioned2015-11-24T18:52:56Z
dc.date.available2015-11-24T18:52:56Z
dc.identifier.issn1234-1010-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/18459
dc.rightsDefault Licence-
dc.subjectAntiviral Agents/*adverse effectsen
dc.subjectFemaleen
dc.subjectHepatitis C, Chronic/*drug therapyen
dc.subjectHumansen
dc.subjectInterferon-alpha/*adverse effectsen
dc.subjectLung Diseases/diagnosis/*etiologyen
dc.subjectMiddle Ageden
dc.subjectRecombinant Proteinsen
dc.subjectSarcoidosis/diagnosis/*etiologyen
dc.titleSarcoidosis associated with interferon-alpha therapy for chronic hepatitis Cen
heal.abstractBACKGROUND: Recombinant interferon-alpha (IFN-alpha ) is widely used for the treatment of chronic hepatitis C. Pulmonary side effects of IFN-alpha therapy seem to be rare. So far, only a few cases of sarcoidosis in association with IFN-alpha treatment of chronic hepatitis C have been CASE REPORT: A 52-year-old woman with chronic hepatitis C developed sarcoidosis during treatment with IFN-alpha. Diagnosis of sarcoidosis was based on chest imaging studies, the increased serum angiotensin converting enzyme levels, and the histology of a biopsied cervical lymph node. Spontaneous remission was observed following IFN-alpha withdrawal. CONCLUSIONS: Use of recombinant IFN-alpha in patients with chronic hepatitis C may trigger or contribute to the development of sarcoidosis in susceptible individuals. Patients should be monitored during and following IFN-alpha therapy for the occurrence of manifestations suggesting sarcoidosis.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/14704637-
heal.journalNameMed Sci Moniten
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2004-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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