Sulindac and indomethacin suppress the diuretic action of furosemide in patients with cirrhosis and ascites: evidence that sulindac affects renal prostaglandins

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dc.contributor.authorDaskalopoulos, G.en
dc.contributor.authorKronborg, I.en
dc.contributor.authorKatkov, W.en
dc.contributor.authorGonzalez, M.en
dc.contributor.authorLaffi, G.en
dc.contributor.authorZipser, R. D.en
dc.date.accessioned2015-11-24T18:49:43Z
dc.date.available2015-11-24T18:49:43Z
dc.identifier.issn0272-6386-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/17997
dc.rightsDefault Licence-
dc.subjectAnti-Inflammatory Agents/pharmacologyen
dc.subjectAscites/drug therapy/urineen
dc.subjectClinical Trials as Topicen
dc.subjectCreatinine/urineen
dc.subjectDinoprostoneen
dc.subjectDiuresis/drug effectsen
dc.subjectDrug Evaluationen
dc.subjectFurosemide/*antagonists & inhibitorsen
dc.subjectHumansen
dc.subjectIndenes/*pharmacologyen
dc.subjectIndomethacin/therapeutic useen
dc.subjectLiver Cirrhosis/*drug therapy/urineen
dc.subjectNatriuresis/drug effectsen
dc.subjectPotassium/urineen
dc.subjectProstaglandin Antagonists/pharmacologyen
dc.subjectProstaglandins E/urineen
dc.subjectSodium/urineen
dc.subjectSulindac/*pharmacologyen
dc.titleSulindac and indomethacin suppress the diuretic action of furosemide in patients with cirrhosis and ascites: evidence that sulindac affects renal prostaglandinsen
heal.abstractNonsteroidal anti-inflammatory drugs (NSAID) suppress prostaglandin-dependent renal blood flow and furosemide-induced diuresis in patients with cirrhosis and ascites. Since sulindac may selectively spare inhibition of renal prostaglandins, we evaluated the interactions of acute administration of sulindac or indomethacin with furosemide in 15 patients with cirrhosis and ascites. Prior to furosemide, indomethacin reduced creatinine clearance (by 55%), urinary volume (by 82%), sodium (by 93%), and prostaglandin E2 (by 87%) (all P less than 0.05), whereas sulindac had no effect. However, both drugs reduced furosemide-induced diuresis. Indomethacin appeared slightly more potent in reducing the diuresis (55% v 38%), natriuresis (67% v 52%), and prostaglandin E2 (PGE2) release (81% v 74%). In a similar protocol in healthy subjects, furosemide-induced diuresis and natriuresis were also blunted by both drugs. Thus, under conditions of enhanced prostaglandin activity from furosemide, sulindac does affect renal function. These data suggest that renal function should be monitored in patients with cirrhosis and ascites who receive sulindac as well as other NSAID.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/3901735-
heal.journalNameAm J Kidney Disen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1985-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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