Estrogen receptor beta gene variants may be associated with more favorable metabolic profile in postmenopausal women undergoing coronary angiography

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dc.contributor.authorSaltiki, K.en
dc.contributor.authorMantzou, E.en
dc.contributor.authorDoukas, C.en
dc.contributor.authorKanakakis, I.en
dc.contributor.authorZotos, P.en
dc.contributor.authorLazaros, L.en
dc.contributor.authorGeorgiou, I.en
dc.contributor.authorAlevizaki, M.en
dc.date.accessioned2015-11-24T19:18:05Z
dc.date.available2015-11-24T19:18:05Z
dc.identifier.issn1439-3646-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21841
dc.rightsDefault Licence-
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectAngiographyen
dc.subjectBody Mass Indexen
dc.subjectChi-Square Distributionen
dc.subjectCoronary Angiographyen
dc.subjectCoronary Artery Disease/genetics/metabolism/radiographyen
dc.subjectCoronary Stenosis/*genetics/metabolism/radiographyen
dc.subjectEstradiol/blooden
dc.subjectEstrogen Receptor beta/*genetics/metabolismen
dc.subjectFemaleen
dc.subjectGenetic Predisposition to Disease/geneticsen
dc.subjectHumansen
dc.subjectInsulin/blooden
dc.subjectMetabolome/*geneticsen
dc.subjectMiddle Ageden
dc.subjectPatient Selectionen
dc.subjectPolymorphism, Genetic/genetics/physiologyen
dc.subjectPostmenopause/*genetics/metabolismen
dc.subjectRegression Analysisen
dc.subjectRisk Factorsen
dc.subjectSeverity of Illness Indexen
dc.subjectStatistics, Nonparametricen
dc.titleEstrogen receptor beta gene variants may be associated with more favorable metabolic profile in postmenopausal women undergoing coronary angiographyen
heal.abstractAIM: Estrogen action is exerted on the vasculature through estrogen receptors ER alpha and ER beta. We have previously reported significant association of ER alpha gene (ESR1) variants with more severe coronary artery disease (CAD) in postmenopausal women. The influence of ER beta gene (ESR2) variants on the cardiovascular system is not well established. We investigated the association of common ESR2 variants with risk factors for cardiovascular disease and with the severity of CAD in postmenopausal women. METHODS: ESR2 polymorphisms Alu I (1730 G > A) and Rsa I (1082 G > A) were studied in 174 postmenopausal women undergoing coronary angiography (age 45 - 88 yrs). The severity of CAD (0 - 3 vessels with > 50 % stenosis), indices of obesity and other predisposing risk factors for cardiovascular disease, biochemical and hormonal parameters were recorded. RESULTS: 75 women had 0, 39 had one, 37 had two and 23 had three vessels with severe stenosis in the coronary angiography. There was no association between Alu I (allele frequency = 40.2 %) and Rsa I (allele frequency = 2.6 %) variants and CAD severity. Carriers of Alu I had lower BMI (p = 0.044), lower waist perimeter (p = 0.029) and lower total cholesterol (p = 0.033) and LDL levels (p = 0.029). There was no association between Rsa I polymorphism and any metabolic risk factors. CONCLUSIONS: ESR2 Alu I polymorphism may have a favorable influence on risk factors for cardiovascular disease such as obesity indices and cholesterol levels. It does not appear to be associated with the severity of CAD in women.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/19938352-
heal.journalNameExp Clin Endocrinol Diabetesen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2009-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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