Association of estrogen receptor gene polymorphisms with endometriosis

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dc.contributor.authorGeorgiou, I.en
dc.contributor.authorSyrrou, M.en
dc.contributor.authorBouba, I.en
dc.contributor.authorDalkalitsis, N.en
dc.contributor.authorPaschopoulos, M.en
dc.contributor.authorNavrozoglou, I.en
dc.contributor.authorLolis, D.en
dc.date.accessioned2015-11-24T19:34:53Z
dc.date.available2015-11-24T19:34:53Z
dc.identifier.issn0015-0282-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23660
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAllelesen
dc.subjectCase-Control Studiesen
dc.subjectEndometriosis/*geneticsen
dc.subjectFemaleen
dc.subjectGene Frequencyen
dc.subjectGenetic Linkageen
dc.subjectHomozygoteen
dc.subjectHumansen
dc.subjectPolymorphism, Genetic/*geneticsen
dc.subjectReceptors, Estrogen/*geneticsen
dc.subjectRepetitive Sequences, Nucleic Aciden
dc.titleAssociation of estrogen receptor gene polymorphisms with endometriosisen
heal.abstractOBJECTIVE: To explore the association of the estrogen receptor two-allele (point) polymorphism and multiallele (microsatellite) polymorphism with endometriosis. DESIGN: Case-control study. SETTING: Genetics and Endoscopy Unit, Department of Obstetrics and Gynecology, Ioannina University HOSPITAL, Ioannina, Greece. PATIENT(S): Fifty-seven women with surgically and histologically diagnosed endometriosis of stages I-IV. INTERVENTION(S): Diagnostic laparoscopy. MAIN OUTCOME MEASURE(S): Frequency and distribution of the estrogen receptor gene polymorphisms. RESULT(S): There was a statistically significant difference between the patients and the controls in the frequency of the two-allele Pvu II polymorphism (0.72 vs. 0.49) and in the median repeats of the (TA)n multiallele polymorphism (15 vs. 20 repeats). In both groups, linkage was found between the fewer (TA)n repeats (range, 12-19) and the positive Pvu II polymorphism. CONCLUSION(S): The variability of the estrogen receptor gene likely contributes to the pathogenesis of endometriosis.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/10428168-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0015028299001983/1-s2.0-S0015028299001983-main.pdf?_tid=03072bfec72c4831624fcb7f14e438b5&acdnat=1333008479_4d94c623cfde194c07f7e088ac749506-
heal.journalNameFertil Sterilen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1999-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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