A diepitopic sequential oligopeptide carrier (SOCn) as mimic of the Sm autoantigen: Synthesis, conformation and biological assays
Φόρτωση...
Ημερομηνία
Συγγραφείς
Alexopoulos, C.
Tsikaris, V.
Rizou, C.
Panou-Pomonis, E.
Sakarellos-Daitsiotis, M.
Sakarellos, C.
Vlachoyiannopoulos, P. G.
Moutsopoulos, H. M.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Wiley
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Journal of Peptide Science
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Anti-Sm (Sm: U1-U6 RNA-protein complex) antibodies are usually considered highly specific for systemic lupus erythematosus (SLE), while anti-U1RNP (U1RNP: U1RNA-protein complex) are thought of as diagnostic criteria for the mixed connective tissue disease (MCTD). However, both antibody specificities coexist in SLE and MCTD, in varying percentages. Although the anti-Sm/anti-U1RNP immunological cross-reactivity has been initially attributed to a common motif, PPXY(Z)PP (where X, Y, Z are various amino acids), found in the Sm, U1-A and U1-C autoantigens, it appears that the conformational features of the Sm epitopes also play an important role in the immunoreactivity. The PPGMRPP and PPGIRGP main epitopes of the Sm antigen were coupled in duplicate to the tetrameric Ac-(Lys-Aib-Gly)(4)-OH, SOC4, carrier to form the [(PPGMRPP)(2), (PPGIRGP)(2)]-SOC4 construct as a mimic of the native Sm. It was found that: (i) the 3(10) helical structure of SOC, allows the epitopes to adopt an exposed orientation, similar to their free forms, that facilitates their recognition from the anti-Sm antibodies, and (ii) the U1-RNP cross-reactivity is minimized. Copyright (C) 2001 European Peptide Society and John Wiley & Sons, Ltd.
Περιγραφή
Λέξεις-κλειδιά
carrier of the sm epitopes, diepitopic sequential oligopeptide carrier, nmr study of socn, sequential oligopeptide carriers (soc)(n), sm autoantigen, sm epitopes grafted to socn, sm mimic, glycopeptide dendrimers, repetitive epitope, antigenic peptides, residual water, autoantibodies, protection, allyl
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000167522100005
http://onlinelibrary.wiley.com/store/10.1002/psc.302/asset/302_ftp.pdf?v=1&t=h0e0j7j6&s=7f7b00c74a7993fb8568de3020ff82af17d27409
http://onlinelibrary.wiley.com/store/10.1002/psc.302/asset/302_ftp.pdf?v=1&t=h0e0j7j6&s=7f7b00c74a7993fb8568de3020ff82af17d27409
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας