Large-scale analysis of association between polymorphisms in the transforming growth factor beta 1 gene (TGFB1) and osteoporosis: the GENOMOS study
Φόρτωση...
Ημερομηνία
Συγγραφείς
Langdahl, B. L.
Uitterlinden, A. G.
Ralston, S. H.
Trikalinos, T. A.
Balcells, S.
Brandi, M. L.
Scollen, S.
Lips, P.
Lorenc, R.
Obermayer-Pietsch, B.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Bone
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
INTRODUCTION: The TGFB1 gene which encodes transforming growth factor beta 1, is a strong candidate for susceptibility to osteoporosis and several studies have reported associations between bone mineral density (BMD), osteoporotic fractures and polymorphisms of TGFB1, although these studies have yielded conflicting results. METHODS: We investigated associations between TGFB1 polymorphisms and BMD and fracture in the GENOMOS study: a prospective multicenter study involving 10 European research studies including a total of 28,924 participants. Genotyping was conducted for known TGFB1 polymorphisms at the following sites: G-1639-A (G-800-A, rs1800468), C-1348-T (C-509-T, rs1800469), T29-C (Leu10Pro, rs1982073), G74-C (Arg25Pro, rs1800471) and C788-T (Thr263Ile, rs1800472). These polymorphisms were genotyped prospectively and methodology was standardized across research centers. Genotypes and haplotypes were related to BMD at the lumbar sine and femoral neck and fractures. RESULTS: There were no significant differences in either women or men at either skeletal site for any of the examined polymorphisms with the possible exception of a weak association with reduced BMD (-12 mg/cm2) in men with the T-1348 allele (p<0.05). None of the haplotypes was associated with BMD and none of the polymorphisms or haplotypes significantly affected overall risk of fractures, however, the odds ratio for incident vertebral fracture in carriers of the rare T788 allele was 1.64 (95% CI: 1.09-2.64), p<0.05. CONCLUSIONS: This study indicates that polymorphic variation in the TGFB1 gene does not play a major role in regulating BMD or susceptibility to fractures. The weak associations we observed between the C-1348-T and lumbar spine BMD in men and between C788-T and risk of incident vertebral fractures are of interest but could be chance findings and will need replication in future studies.
Περιγραφή
Λέξεις-κλειδιά
Adult, Aged, Aged, 80 and over, Bone Density, Case-Control Studies, Cohort Studies, Cross-Sectional Studies, Female, Femur Neck/metabolism, Fractures, Bone/genetics, Gene Frequency, Genotype, Humans, Logistic Models, Lumbar Vertebrae/metabolism, Male, Middle Aged, Odds Ratio, Osteoporosis/*genetics/metabolism/pathology, *Polymorphism, Single Nucleotide, Sex Factors, Spinal Fractures/genetics, Transforming Growth Factor beta1/*genetics
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/18284942
http://ac.els-cdn.com/S8756328207008605/1-s2.0-S8756328207008605-main.pdf?_tid=179225f5d648aa1d020cc9c90390a88e&acdnat=1333363854_cbb9dfe8d45fa1c6480d107a3b6a303a
http://ac.els-cdn.com/S8756328207008605/1-s2.0-S8756328207008605-main.pdf?_tid=179225f5d648aa1d020cc9c90390a88e&acdnat=1333363854_cbb9dfe8d45fa1c6480d107a3b6a303a
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής