Lipid abnormalities in Greek patients with coronary artery disease
Φόρτωση...
Ημερομηνία
Συγγραφείς
Elisaf, M. S.
Siamopoulos, K. C.
Tselegarides, T. J.
Bairaktari, E. T.
Goudevenos, J. A.
Tselepis, A. D.
Tsolas, O. E.
Sideris, D. A.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Int J Cardiol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Lipid abnormalities are major risk factors for premature coronary artery disease (CAD). However, the type and prevalence of dyslipidemia in these patients have not been well characterised, especially in some ethnic groups. The purpose of the present work was to determine the lipid disorders in patients of Northwestern Greece with premature CAD. The study population comprised of 132 men and 38 women who underwent elective diagnostic arteriography in our University Hospital. Subjects with greater than or equal to 1 lesion that narrowed the lumen of any of the 15 coronary artery segments by greater than or equal to 70% were considered to be CAD cases (n=108), whereas those with narrowing <70% were excluded (n=54). Asymptomatic subjects (n=104) matched for age and sex were taken as controls. Compared with the controls, patients with premature CAD had increased serum levels of total cholesterol, LDL cholesterol, triglycerides, Apo B, and Lp(a), and decreased serum levels of HDL cholesterol and Apo A1. A lipoprotein or apolipoprotein abnormality was identified in 89 CAD patients (82.4%). The increased serum Apo B level (>130 mg/dl) was the most common lipid abnormality observed in 72 patients. However, the most prevalent dyslipidemic phenotypes in our patients were type IIA followed by hypoalpha and hyperApoB. Compared to the control population, CAD patients had increased incidence of IIA and hypoalpha phenotypes. On the contrary, a normal lipoprotein phenotype was more common in the control population compared to CAD patients (56.7% vs. 17.6%, P<0.001). We conclude that the majority of Creek patients with premature CAD exhibit lipid and lipoprotein abnormalities, which to a large extent can be defined by determining the traditional lipid parameters (total cholesterol, LDL cholesterol, HDL cholesterol and triglycerides). However, in some cases the value of the quantification of other lipid parameters such as apolipoproteins and Lp(a) should be taken into account. (C) 1997 Elsevier Science Ireland Ltd.
Περιγραφή
Λέξεις-κλειδιά
coronary artery disease, lipid parameters, lipoprotein phenotypes, apolipoprotein b, lipoprotein (a), ischemic-heart-disease, apolipoprotein-a-i, myocardial-infarction, serum-cholesterol, risk-factors, lipoprotein, men, association, hyperapobetalipoproteinemia, prevalence
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://A1997WY18500012
http://ac.els-cdn.com/S0167527396029166/1-s2.0-S0167527396029166-main.pdf?_tid=9394bbfff28a70dec09b9c1bf18b440d&acdnat=1333111107_8eab9851d09ed2e11b5ca73a0540cf90
http://ac.els-cdn.com/S0167527396029166/1-s2.0-S0167527396029166-main.pdf?_tid=9394bbfff28a70dec09b9c1bf18b440d&acdnat=1333111107_8eab9851d09ed2e11b5ca73a0540cf90
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας