Temporal relations between unexplained fatigue and depression: longitudinal data from an international study in primary care

dc.contributor.authorSkapinakis, P.en
dc.contributor.authorLewis, G.en
dc.contributor.authorMavreas, V.en
dc.date.accessioned2015-11-24T19:42:47Z
dc.date.available2015-11-24T19:42:47Z
dc.identifier.issn1534-7796-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24691
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectComorbidityen
dc.subject*Cross-Cultural Comparisonen
dc.subjectCross-Sectional Studiesen
dc.subjectDepressive Disorder/*diagnosis/epidemiologyen
dc.subjectFatigue Syndrome, Chronic/*diagnosis/epidemiologyen
dc.subjectFemaleen
dc.subjectFollow-Up Studiesen
dc.subjectHealth Statusen
dc.subjectHealth Surveysen
dc.subjectHumansen
dc.subjectInternational Classification of Diseasesen
dc.subjectLogistic Modelsen
dc.subjectLongitudinal Studiesen
dc.subjectMaleen
dc.subjectNeurasthenia/*diagnosis/epidemiologyen
dc.subjectOdds Ratioen
dc.subjectPrevalenceen
dc.subjectPrimary Health Care/*statistics & numerical dataen
dc.subjectPsychiatric Status Rating Scalesen
dc.subjectQuestionnairesen
dc.subjectRisk Factorsen
dc.subjectWorld Health Organizationen
dc.titleTemporal relations between unexplained fatigue and depression: longitudinal data from an international study in primary careen
heal.abstractOBJECTIVE: Unexplained fatigue syndromes, such as chronic fatigue syndrome and neurasthenia, are strongly associated with depression, but the temporal nature of this association is not clear. METHODS: The authors examined this issue by using data from the World Health Organization collaborative study of psychological problems in general health care. Three thousand two hundred one subjects from 15 primary care centers in 14 countries were followed up for 12 months. The Composite International Diagnostic Interview was the main instrument used. Odds ratios and their 95% confidence intervals (CI) were calculated using logistic regression models adjusted for sociodemographic variables, physical morbidity and intercenter variability. RESULTS: Cases of depression were found to have an increased risk of developing a new episode of unexplained fatigue at follow-up with an adjusted odds ratio of 4.15 (95% CI = 2.64-6.54). Similarly, cases of unexplained fatigue were found to have an increased risk of developing a new episode of depression at follow-up with an adjusted odds ratio of 2.76 (95% CI = 1.32-5.78). Further adjustment for subthreshold symptoms at baseline weakened the reported associations, especially between fatigue and development of a new episode of depression, but these remained significant. CONCLUSIONS: The findings support the view that unexplained fatigue and depression might act as independent risk factors for each other.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/15184691-
heal.journalNamePsychosom Meden
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2004-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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