Blastic natural killer (NK)-cell lymphoma: report of an unusual CD4 negative case and review of the CD4 negative neoplasms with blastic features in the literature

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dc.contributor.authorArgyrakos, T.en
dc.contributor.authorRontogianni, D.en
dc.contributor.authorKarmiris, T.en
dc.contributor.authorKapsimali, V.en
dc.contributor.authorGrigoriou, E.en
dc.contributor.authorTsantekidou, M.en
dc.contributor.authorNaum, C.en
dc.contributor.authorGalani, V.en
dc.contributor.authorPantelidaki, C.en
dc.contributor.authorHarhalakis, N.en
dc.contributor.authorNikiforakis, E.en
dc.contributor.authorKanavaros, P.en
dc.date.accessioned2015-11-24T19:32:44Z
dc.date.available2015-11-24T19:32:44Z
dc.identifier.issn1042-8194-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23448
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAntigens, CD4/analysisen
dc.subjectBlast Crisisen
dc.subjectBone Marrow Neoplasmsen
dc.subjectDiagnosis, Differentialen
dc.subjectFatal Outcomeen
dc.subjectHumansen
dc.subjectImmunophenotypingen
dc.subjectIn Situ Hybridizationen
dc.subjectKiller Cells, Natural/*pathologyen
dc.subjectLymphoma, Non-Hodgkin/diagnosis/*pathologyen
dc.subjectMaleen
dc.subjectNeoplasm Invasivenessen
dc.subjectRNA, Viral/analysisen
dc.subjectSkin Neoplasmsen
dc.subjectVidarabine/adverse effects/*analogs & derivatives/therapeutic useen
dc.titleBlastic natural killer (NK)-cell lymphoma: report of an unusual CD4 negative case and review of the CD4 negative neoplasms with blastic features in the literatureen
heal.abstractBlastic Natural Killer (NK)-cell lymphoma is a relatively new entity which has been recently included in the WHO classification. CD4 expression is observed in most cases of blastic NK-cell lymphomas and has been related with skin tropism. We report an unusual CD4 negative blastic NK-cell lymphoma with primary presentation in the skin, subsequent infiltration of the bone marrow and aggressive behavior. It is emphasized that extensive immunophenotyping and EBER RNA in situ hybridization are required in order to establish the diagnosis of blastic NK-cell lymphoma. We also present a review of the literature with respect to the CD4 negative NK-cell lymphomas with blastic morphological features.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1080/10428190410001723232-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/15370260-
heal.identifier.secondaryhttp://informahealthcare.com/doi/abs/10.1080/10428190410001723232-
heal.journalNameLeuk Lymphomaen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2004-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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