Synthetic analogs for oxovanadium(IV/V)-glutathione interaction: an NMR, EPR, synthetic and structural study of oxovanadium(IV/V) compounds with sulfhydryl-containing pseudopeptides and dipeptides

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dc.contributor.authorTasiopoulos, A. J.en
dc.contributor.authorTroganis, A. N.en
dc.contributor.authorDeligiannakis, Y.en
dc.contributor.authorEvangelou, A.en
dc.contributor.authorKabanos, T. A.en
dc.contributor.authorWoollins, J. D.en
dc.contributor.authorSlawin, A.en
dc.date.accessioned2015-11-24T16:32:27Z
dc.date.available2015-11-24T16:32:27Z
dc.identifier.issn0162-0134-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/7554
dc.rightsDefault Licence-
dc.subjectoxovanadium(iv) compoundsen
dc.subjectsulfhydryl-containing pseudopeptides and dipeptidesen
dc.subjectepr spectroscopyen
dc.subjectnmr spectroscopyen
dc.subjectparamagnetic-res characterizationen
dc.subjectvanadium bioinorganic systemsen
dc.subjectspin-resonance-spectraen
dc.subjectspectroscopic propertiesen
dc.subjectmodel investigations|en
dc.titleSynthetic analogs for oxovanadium(IV/V)-glutathione interaction: an NMR, EPR, synthetic and structural study of oxovanadium(IV/V) compounds with sulfhydryl-containing pseudopeptides and dipeptidesen
heal.abstractThe reaction of [VO(CH3COO)(2)(phen)] (phen=1,10-phenanthroline) with the sulfhydryl-containing pseudopeptides (scp), N-(2-mercaptopropionyl) glycine (H(3)mpg), N-(2-mercaptopropionyl) cysteine (H(4)m(2)pc), N-(3-mercaptopropionyl)cysteine (H(4)m(3)pc) and the dipeptides glycylglycine (H(2)glygly) and glycyl-L-alanine (H(2)glyala), in the presence of triethylamine, results in the formation of the compounds Et3NH[VO(mpg)(phen)] (1), (Et3NH)(2)[VO(m(2)pc)] (4), [Et3NH)(2)[VO(m(3)pc)] (5), [VO(glygly)(phen)] . 2CH(3)OH (2 . 2CH(3)OH) and [VO(glyala)(phen)] . CH3OH (3 . CH3OH). Evidence for the molecular connectivity in 2 . CH3OH was established by X-ray crystallography, showing the vanadium(IV) atom ligated to a tridentate glygly(2-) ligand at the N-amine, N-peptide and O-carboxylato atoms. Combination of the correlation plot of the EPR parameters g(z) versus A(z), together with the additivity relationship supported the prediction of the equatorial donor atom sets of the (VO2+)-O-IV center at various pH values for the (VO2+)-O-IV-glutathione system considered in this study. Model NMR studies (interaction of vanadium(V) with the sep H(3)mpg) showed that there is a possibility of vanadium(V) ligation to glutathione. (C) 2000 Elsevier Science Inc. All rights reserved.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondary<Go to ISI>://000086988500024-
heal.journalNameJ Inorg Biochemen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2000-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιώνel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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