Overexpression of C-myc, Ras and C-erbB-2 oncoproteins in carcinoma of unknown primary origin

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dc.contributor.authorPavlidis, N.en
dc.contributor.authorBriassoulis, E.en
dc.contributor.authorBai, M.en
dc.contributor.authorFountzilas, G.en
dc.contributor.authorAgnantis, N.en
dc.date.accessioned2015-11-24T19:00:27Z
dc.date.available2015-11-24T19:00:27Z
dc.identifier.issn0250-7005-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19534
dc.rightsDefault Licence-
dc.subjectAdenocarcinoma/genetics/metabolism/secondaryen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectCarcinoma/genetics/metabolism/*secondaryen
dc.subjectCarcinoma, Squamous Cell/genetics/pathology/secondaryen
dc.subjectFemaleen
dc.subject*Gene Expression Regulation, Neoplasticen
dc.subjectHumansen
dc.subjectImmunoenzyme Techniquesen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectNeoplasm Proteins/*biosynthesis/geneticsen
dc.subject*Neoplasms, Unknown Primaryen
dc.subjectProto-Oncogene Proteins c-myc/*biosynthesis/geneticsen
dc.subjectProto-Oncogene Proteins p21(ras)/*biosynthesis/geneticsen
dc.subjectReceptor, erbB-2/*biosynthesis/geneticsen
dc.titleOverexpression of C-myc, Ras and C-erbB-2 oncoproteins in carcinoma of unknown primary originen
heal.abstractThe role of oncogenes in carcinoma of unknown primary site (CUP) has not yet been elucidated. In the present study the expression of the c-myc p62, ras p21 and c-erB-2 p185 oncoproteins were studied by a 3-step immunoperoxidase technique in 26 cases of CUP. Positive immunoreactivity was observed in 96% of the cases for c-myc, 92% for ras and in 65% for c-erb-2, with at least half of tumor cells labelled in 85%, 92% and 58% respectively. The degree of staining intensity was considered moderate or strong in more than half of the cases for all oncogene products. In conclusion, our results showed that patients with CUP have an extremely high overexpression of all three oncogenes studied. Nevertheless, the biological role of these overexpressed oncoproteins, their relationship with different histological or clinical parameters and their diagnostic or prognostic value need further evaluation.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/8669824-
heal.journalNameAnticancer Resen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1995-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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