Prothymosin alpha is localized in mitotic spindle during mitosis
| dc.contributor.author | Vareli, K. | en |
| dc.contributor.author | Frangou-Lazaridis, M. | en |
| dc.date.accessioned | 2015-11-24T18:55:50Z | |
| dc.date.available | 2015-11-24T18:55:50Z | |
| dc.identifier.issn | 0248-4900 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/18938 | |
| dc.rights | Default Licence | - |
| dc.subject | Animals | en |
| dc.subject | Antineoplastic Agents/metabolism | en |
| dc.subject | Cell Line | en |
| dc.subject | Centrosome/metabolism | en |
| dc.subject | Humans | en |
| dc.subject | Mitosis/*physiology | en |
| dc.subject | Mitotic Spindle Apparatus/*metabolism | en |
| dc.subject | Nocodazole/metabolism | en |
| dc.subject | Protein Precursors/*metabolism | en |
| dc.subject | Thymosin/*analogs & derivatives/metabolism | en |
| dc.subject | Tubulin/metabolism | en |
| dc.title | Prothymosin alpha is localized in mitotic spindle during mitosis | en |
| heal.abstract | Prothymosin a is a small, acidic, ubiquitous protein, thought to play a role in cell proliferation, carcinogenesis and apoptosis. We have reported earlier that in the interphase nucleus prothymosin a exhibits a punctuated nuclear distribution associated with transcription sites. Moreover, the protein was found to localize in 1-6 subnuclear domains where PML and CstF64 proteins were also identified. In the present study we followed the subcellular distribution of prothymosin a during mitosis. Our data identify prothymosin a to colocalize with alpha-tubulin in the mitotic spindle throughout mitosis, and to decorate the midbody during cytokinesis. Moreover nocodazole treatment disrupted prothymosin alpha and alpha-tubulin colocalization at the centrosomes of the interphase cell. Prothymosin a was also found to decorate gamma-tubulin identified centrosomes, during mitosis. Taken together our colocalization study suggests involvement of prothymosin a, in the formation, maintenance, or functioning of the mitotic spindle. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1016/j.biolcel.2004.04.002 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/15325071 | - |
| heal.identifier.secondary | http://onlinelibrary.wiley.com/store/10.1016/j.biolcel.2004.04.002/asset/j.biolcel.2004.04.002.pdf?v=1&t=h0bz4i5y&s=a440c872b0a24ae1b6e0f915ef2c6b08ff5e6b08 | - |
| heal.journalName | Biol Cell | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2004 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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