Novel roles of vitamin D in disease: what is new in 2011?
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Makariou, S.
Liberopoulos, E. N.
Elisaf, M. S.
Challa, A.
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peer-reviewed
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Eur J Intern Med
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Vitamin D is a steroid molecule, mainly produced in the skin that regulates the expression of a large number of genes. Until recently its main known role was to control bone metabolism and calcium and phosphorus homeostasis. During the last 2 decades it has been realized that vitamin D deficiency, which is really common worldwide, could be a new risk factor for many chronic diseases, such as the metabolic syndrome and its components, the whole spectrum of cardiovascular diseases, several auto-immune conditions, and many types of cancer as well as all-cause mortality. Except for the great number of epidemiological studies that support the above presumptions, vitamin D receptors (VDRs) have been identified in many tissues and cells. The effect of vitamin D supplementation remains controversial and the need for more persuasive study outcomes is intense.
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Keywords
*Cardiovascular Diseases/epidemiology/etiology/metabolism, Homeostasis, Humans, Morbidity/trends, Risk Factors, Vitamin D/*metabolism, *Vitamin D Deficiency/complications/epidemiology/metabolism
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http://www.ncbi.nlm.nih.gov/pubmed/21767752
http://ac.els-cdn.com/S0953620511000914/1-s2.0-S0953620511000914-main.pdf?_tid=ccf54270fc5e1743708642a3f5caa086&acdnat=1332919328_bbc09fd6be3906ade296f6153d5da009
http://ac.els-cdn.com/S0953620511000914/1-s2.0-S0953620511000914-main.pdf?_tid=ccf54270fc5e1743708642a3f5caa086&acdnat=1332919328_bbc09fd6be3906ade296f6153d5da009
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en
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Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής