Combination chemotherapy with gemcitabine and vinorelbine in the treatment of relapsed or refractory diffuse large B-cell lymphoma: a phase-II trial by the Hellenic Cooperative Oncology Group
Φόρτωση...
Ημερομηνία
Συγγραφείς
Papageorgiou, E. S.
Tsirigotis, P.
Dimopoulos, M.
Pavlidis, N.
Fountzilas, G.
Papageorgiou, S.
Economopoulos, T.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Eur J Haematol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
To investigate the efficacy and toxicity of the combination of gemcitabine and vinorelbine in patients with relapsed or refractory diffuse large B-cell lymphoma (DLBL), 22 patients with relapsed or refractory DLBL were treated with gemcitabine 1000 mg/m2 and vinorelbine 30 mg/m2 on days 1 and 8 every 3 wk for a maximum of six cycles. Fourteen patients were considered chemosensitive while eight patients were considered chemoresistant to the last treatment regimen. All 22 patients were assessed for response to treatment. Three patients (14%) achieved complete remission and eight patients (36%) had partial remission of their disease, with an overall response rate of 50%. With a median follow up of 44 months, the median time to progression (TTP) for all patients was 8.1 months while the median overall survival (OS) was 12.9 months. Toxicity was minimal and all patients were treated on an outpatient basis. The combination of gemcitabine and vinorelbine is an effective and well-tolerated regimen for patients with relapsed of refractory DLBL.
Περιγραφή
Λέξεις-κλειδιά
Adult, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols/*administration & dosage/toxicity, Deoxycytidine/administration & dosage/*analogs & derivatives, Female, Humans, Lymphoma, B-Cell/drug therapy, Lymphoma, Large B-Cell, Diffuse/*drug therapy, Male, Middle Aged, Remission Induction, Salvage Therapy/*methods, Survival Analysis, Vinblastine/administration & dosage/*analogs & derivatives
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/16000128
http://onlinelibrary.wiley.com/store/10.1111/j.1600-0609.2005.00482.x/asset/j.1600-0609.2005.00482.x.pdf?v=1&t=h0nicf9w&s=195eee210035d7b43f39aea1cc3603a3bec9bacb
http://onlinelibrary.wiley.com/store/10.1111/j.1600-0609.2005.00482.x/asset/j.1600-0609.2005.00482.x.pdf?v=1&t=h0nicf9w&s=195eee210035d7b43f39aea1cc3603a3bec9bacb
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής