Allergic reactions to local glyceryl trinitrate administration

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dc.contributor.authorKounis, N. G.en
dc.contributor.authorZavras, G. M.en
dc.contributor.authorPapadaki, P. J.en
dc.contributor.authorSoufras, G. D.en
dc.contributor.authorPoulos, E. A.en
dc.contributor.authorGoudevenos, J.en
dc.contributor.authorAlangoussis, A.en
dc.contributor.authorAntonakopoulos, K.en
dc.contributor.authorFrangides, C.en
dc.contributor.authorPeristeropoulou, S. A.en
dc.contributor.authorKoutsojannis, C.en
dc.date.accessioned2015-11-24T19:37:03Z
dc.date.available2015-11-24T19:37:03Z
dc.identifier.issn0007-0947-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23982
dc.rightsDefault Licence-
dc.subjectAdhesives/adverse effectsen
dc.subjectAdministration, Cutaneousen
dc.subjectAgeden
dc.subjectAngina Pectoris/drug therapyen
dc.subjectDermatitis, Contact/etiologyen
dc.subjectDrug Administration Scheduleen
dc.subjectDrug Eruptions/*etiologyen
dc.subjectFemaleen
dc.subjectGlycerol/adverse effectsen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectMyocardial Ischemia/drug therapyen
dc.subjectNitroglycerin/administration & dosage/*adverse effectsen
dc.subjectPatch Testsen
dc.subjectSilicones/adverse effectsen
dc.titleAllergic reactions to local glyceryl trinitrate administrationen
heal.abstractTo assess the exact cause and extent of transdermal glyceryl trinitrate (GTN)-induced allergic reactions, a study of continuous and intermittent use of GTN patches was conducted in 320 patients with New York Heart Association (NYHA) class II and III angina pectoris. Three commercially available GTN patch systems were used. Twenty-one patients (6.5%) developed cutaneous reactions. In 17 patients (5.3%), the reactions were confined to the area of application and were characterised as irritant reactions. Four patients (1.2%) developed both localised and remote from the area of application lesions and one patient developed a generalised anaphylactic reaction. The rate of discontinuation of therapy was 3.4%. The irritant skin reactions were mainly due to contaminants and additives. Changing to a different transdermal system reduced the incidence of local reactions--a particularly desirable effect in patients who respond well to GTN therapy.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/9039714-
heal.journalNameBr J Clin Practen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1996-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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