D-penicillamine toxicity in Greek patients with rheumatoid arthritis: anti-Ro(SSA) antibodies and cryoglobulinemia are predictive factors
| dc.contributor.author | Vlachoyiannopoulos, P. G. | en |
| dc.contributor.author | Zerva, L. V. | en |
| dc.contributor.author | Skopouli, F. N. | en |
| dc.contributor.author | Drosos, A. A. | en |
| dc.contributor.author | Moutsopoulos, H. M. | en |
| dc.date.accessioned | 2015-11-24T19:23:35Z | |
| dc.date.available | 2015-11-24T19:23:35Z | |
| dc.identifier.issn | 0315-162X | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/22336 | |
| dc.rights | Default Licence | - |
| dc.subject | Antibodies, Antinuclear/*analysis | en |
| dc.subject | Arthritis, Rheumatoid/complications/*drug therapy/ethnology/immunology | en |
| dc.subject | Cryoglobulinemia/*complications | en |
| dc.subject | Drug Eruptions | en |
| dc.subject | Female | en |
| dc.subject | Fluorescent Antibody Technique | en |
| dc.subject | Forecasting | en |
| dc.subject | Greece/ethnology | en |
| dc.subject | Humans | en |
| dc.subject | Male | en |
| dc.subject | Penicillamine/*adverse effects | en |
| dc.title | D-penicillamine toxicity in Greek patients with rheumatoid arthritis: anti-Ro(SSA) antibodies and cryoglobulinemia are predictive factors | en |
| heal.abstract | Sixty-two consecutive patients, with rheumatoid arthritis (RA) who received D-penicillamine were studied retrospectively to identify predictive risk factors for D-penicillamine toxicity. Thirty-two developed side effects, while 30 did not. The clinical picture in both groups was similar, but the group with D-penicillamine toxicity was characterized by a high incidence of anti-Ro(SSA) antibodies (p less than 0.01) or circulating cryoglobulins (p less than 0.001). The presence of anti-Ro(SSA) antibodies was not correlated with the presence of circulating cryoglobulins (p greater than 0.5), while the coefficient of contingency (C) between anti-Ro(SSA) and cryoglobulins was 0.131. Men were predisposed to express more renal pathology (p less than 0.025), while anti-Ro(SSA) positive patients with RA more often expressed rashes (p less than 0.0001) and acute febrile reactions (p less than 0.05) than anti-Ro(SSA) negative patients. These observations should be considered when making therapeutic decisions at least for Greek patients with RA. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/1827158 | - |
| heal.journalName | J Rheumatol | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1991 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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